ANTITUMOR EFFECT OF REACTIVE OXYGEN SPECIES IN ARTIFICIAL ROS-GENERATING SYSTEMS
Keywords:
ROS-generating systems, reactive oxygen species, experimental tumor growth.Abstract
Summary. Objective: to develop a redox system generating
reactive oxygen species (ROS) using non-toxic or low-toxic substances, to study their impact on experimental tumor growth. Object and methods: Lung carcinoma Lewis, Ehrlich carcinoma, P388, C57Bl/6 mice, non breading
mice; biochemical, spectroscopic, electron paramagnetic
resonance, high performance liquid chromatography enzymografy, tumor transplantation and assessment of tumor growth, statistics. Results: the possibility of creating
artificial systems for generation of ROS in the system the
whole organism and in tumor cells has been demonstrated.
Antitumor effect of ROS-generating systems implemented
at both the direct effects on tumor cells, and at the level of
activation of anticancer defense mechanisms of the body.
Conclusion: the research results can be the basis for new
approaches for targeting tumor process.
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