INDICATORS OF ANGIORHEOLOGICAL PROPERTIES OF BLOOD AS MARKERS OF FOLLOW-UP VASCULAR RADIOCHEMOTHERAPY COMPLICATIONS WITH LUNG CANCER
Abstract
Summary. Objective: to evaluate the indicators of
endothelial function of blood vessels (vascular endothelial function — VEF) and adsorption-rheological
blood properties (ARBP) prior to the start of the program of radiochemotherapy in patients with different variants of lung cancer (LC) course, correlation
with the levels of other tumor markers and selection
of parameters that affect follow-up vascular radiochemotherapy complications. Object and methods:
angiorheological parameters in blood serum (VEF
and ARBP) were studied in 115 patients with LC
at the age of 24 to 80 years old, among which there
were 78.3% of men and 21.7% of women. Central
form of LC occurred in 77.4% of cases, peripheral —
in 22.6%. Small-cell variant of LC was detected in
16.5% of patients, non-small-cell — in 83.5%, the
ratio of IA–IB, IIA, IIB, ІІІA, ІІІV, and IV disease
stages was 1:2:23:35:36. Methods of enzyme immunoassay and oscillating drop were used to study the
angiorheological properties of blood serum. As a control, these laboratory parameters were determined in
40 healthy people between the ages of 18 to 62 years.
Statistical analysis of the results of the research was
carried out using computer variational, nonparametric, correlation, regression, one- (ANOVA) and
multivariate (ANOVA/MANOVA) variance analysis (Microsoft Excel and Statistica-Stat-Soft, USA).
Results: the integral nature of vascular complications of radiochemotherapy of LC (pulmonary hypertension, hemoptysis, acute vascular insufficiency,
acute coronary syndrome and acute cerebral circulation disorder, thrombophlebitis, pulmonary artery
thromboembolism, mesenteric vascular thrombosis)
is associated with radical radiotherapy for primary tumor and palliative for distant metastases, has
sexual dimorphism (development of acute vascular
insufficiency in women), is determined by the power of chemotherapy (thromboembolism of pulmonary
artery branches). Changes of blood angiorheological
properties with LC are accompanied by increased parameters of vascular endothelial growth factor, endothelin-1, homocysteine, cyclic guanosine monophosphate, P-selectin, surface indicators of tension,
elasticity and relaxation with decreased prostacyclinemia values. There are correlation relationships
with well-known oncomarkers (transforming growth
factor β1
, fibronectin, ostepontin). Conclusion: vascular radiochemotherapy complications with LC depend on the initial parameters of blood angiorheo
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