ФУНКЦІОНАЛЬНІ НАСЛІДКИ ВЗАЄМОДІЇ ПРОТЕЇНІВ MRPS18-2 ТА RB ПРИ ТРАНСФОРМАЦІЇ КЛІТИНИ
DOI:
https://doi.org/10.32471/oncology.2663-7928.t-23-1-2021-g.9384Ключові слова:
білок RB, злоякісні новоутворення, іморталізація клітини, мітохондріальний рибосомальний протеїн, протеїн MRPS18-2, стовбурові клітини, трансформація клітиниАнотація
Cтаття присвячена аналізу даних наукової літератури та висвітленню власних результатів щодо раніше невідомих функцій мітохондріального рибосомального білка S18-2, який кодовано ядерним геномом. Описана кооперація білків RB і S18-2 у підтриманні фенотипу стовбурових клітин, і порушення балансу їх експресії призводить до виникнення пухлин. Також проаналізовано функціональні наслідки взаємодії протеїнів RB і S18-2 в контролі за стовбуровістю клітин та їх диференціюванням. Представлено дані стосовно того, що білок S18-2 є потужним онкопротеїном. Зроблено припущення, що зниження рівнів протеїну S18-2 може бути потенційно успішною стратегією для лікування пацієнтів зі злоякісними пухлинами.
Посилання
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