STRESS-INDUCED CHANGES IN ANTITUMOR IMMUNITY
DOI:
https://doi.org/10.15407/oncology.2025.03.161Keywords:
стрес, рак, катехоламіни, глюкокортикоїди, мікроелементи, протипухлинний імунітетAbstract
Summary. The results of experimental and clinical studies point to a significant modifying effect of stress on the functioning of both individual physiological systems and the body as a whole, which not only increases the risk of malignant neoplasms, but can also negatively affect the treatment outcomes of cancer patients. In this review article, the authors present an analysis of data from the up to date scientific literature on the relationship between stress and oncogenesis, as well as stress-induced changes in the content of essential trace elements (copper, iron, zinc, ferrum, calcium) which play a key role in many biological processes. Considerable attention is paid to changes in the functions of immunocompetent cells that are part of the tumour microenvironment and mediate the antitumour immune response under conditions of acute and chronic stress.
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