INFLUENCE OF COVID-19 AND VACCINATION AGAINST SARS-COV-2 ON THE COURSE OF ONCOHEMATOLOGICAL DISEASES. 3. ROLE OF INFLAMMATION AND THE EFFECT OF CYTOKINE STORM
DOI:
https://doi.org/10.15407/oncology.2025.01.067Keywords:
COVID-19, SARS-CoV-2, chemokines, interleukins, IL-2, IL-6, IL-8, IL-10, TNF-alpha, vaccination against SARS-CoV-2Abstract
Summary. Aim: to assess the impact of the cytokine storm, what is typical for the course of COVID-19, on vaccination against the SARS-COV-2 virus in patients with chronic lymphocytic leukemia (CLL). The results of bioinformatic analysis, using the DisGeNET database and algorithm showed that, in addition to ACE2, also IL10, C-reactive protein (CRP), ACE, AGT, IL1B and CXCL10 are highly associated with this disease. Bioinformatic analysis, using the FunCoup algorithm showed an association with COVID-19 disease of the cytokine IL6. Using qPCR, we showed that relative expression levels of IL2 slightly, but significantly increases in the blood of CLL patients in case of COVID-19 disease. Vaccination does not affect the IL2 levels. A similar relationship was found for TNFA (TNF-alpha). However, in this case, the level of cytokine increases also during vaccination, although in the presence of COVID-19 the effect of vaccination is leveled. The relative expression of IL10 is slightly reduced during vaccination, but significantly increased in the presence of COVID-19, and for IL6 and IL8 — slightly increased after vaccination, but decreased when patients with COVID-19 were vaccinated. Thus, vaccination of CLL patients against the SARS-CoV-2 virus does not lead to the desired results and does not give an advantage to vaccinated individuals in terms of the course of the COVID-19 disease.
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