RATIOS OF CELLS RELATING TO INNATE AND ADAPTIVE IMMUNE SYSTEM IN SECONDARY (METASTATIC) AND PRIMARY GLIAL CEREBRAL TUMORS
Keywords:
glioblastoma, astrocytoma, fibrillar protoplasmic, metastases to the brain, peripheral blood, platelets, leukocytes, neutrophils, lymphocytes.Abstract
Summary. Objective: of investigations was to study
the content of leukocytes (L), neutrophils (Nph), lym
phocytes (Lym) and platelets (Plt) in the peripheral
blood (PB) (as indicators of the innate and acquired im
mune response and systemic inflammation) in patients
with primary glial and secondary metastatic cerebral tu
mors in preoperative and postoperative periods. Object
and methods: PB indicators were studied in 56 patients
having primary glial (40 glioblastoms, 16 benign cere
bral tumors) and 18 secondary metastatic cerebral tu
mors of different localization. PB values were evaluat
ed on automatic hematologic analyzer MINDRAY BC
3000 plus. Absolute platelet Plt, Nph and Lym counts
were determined as well as the ratios of Plt/Lym, Plt/
Nph, and percentage ratio of Nph/Lym were established.
Results: in patients with glioblastomas and metastat
ic tumors in the preoperative period in the PB, the ab
solute content of L and Nf was increased, the absolute
content of Lf was reduced, the Tr content was not sig
nificantly changed. An increase in the Nf/Lf and Tr/Lf
ratios, as well as a decrease in the Tr/Nf ratios, is pro
portional to the increase in the degree of tumor anapla
sia. In the postoperative period in patients with cerebral
tumors, indirect indicators of the intensity of inflam
matory reactions (leukocytosis, neutrophilia) increase
in comparison with the preoperative period, while the
content of Lf decreases. Conclusions: in patients with
cerebral malignant tumors — primary (glioblastomas)
and secondary (metastases) in the preoperative period,
the same type and unidirectional changes in PB, more
intense with metastases, were established. The revealed
changes may indirectly indicate an increase in the ac
tivity of inflammatory reactions in proportion to the in
crease in the degree of anaplasia of the cerebral tumors
and the suppression of the reactions of the adaptive im
mune response. The ratio Tr/Lf can serve as an addi
tional criterion for the degree of malignancy of cerebral
tumors. An increase in the indices characterizing the in
nate immune system, parallel with a decrease in Lf level,
may indicate a multidirectional (stimulating or suppres
sive) effect on the innate and acquired immunity of ce
rebral malignant tumors (both primary and secondary)
and related surgical treatment.Summary. Objective: of investigations was to study
the content of leukocytes (L), neutrophils (Nph), lym
phocytes (Lym) and platelets (Plt) in the peripheral
blood (PB) (as indicators of the innate and acquired im
mune response and systemic inflammation) in patients
with primary glial and secondary metastatic cerebral tu
mors in preoperative and postoperative periods. Object
and methods: PB indicators were studied in 56 patients
having primary glial (40 glioblastoms, 16 benign cere
bral tumors) and 18 secondary metastatic cerebral tu
mors of different localization. PB values were evaluat
ed on automatic hematologic analyzer MINDRAY BC
3000 plus. Absolute platelet Plt, Nph and Lym counts
were determined as well as the ratios of Plt/Lym, Plt/
Nph, and percentage ratio of Nph/Lym were established.
Results: in patients with glioblastomas and metastat
ic tumors in the preoperative period in the PB, the ab
solute content of L and Nf was increased, the absolute
content of Lf was reduced, the Tr content was not sig
nificantly changed. An increase in the Nf/Lf and Tr/Lf
ratios, as well as a decrease in the Tr/Nf ratios, is pro
portional to the increase in the degree of tumor anapla
sia. In the postoperative period in patients with cerebral
tumors, indirect indicators of the intensity of inflam
matory reactions (leukocytosis, neutrophilia) increase
in comparison with the preoperative period, while the
content of Lf decreases. Conclusions: in patients with
cerebral malignant tumors — primary (glioblastomas)
and secondary (metastases) in the preoperative period,
the same type and unidirectional changes in PB, more
intense with metastases, were established. The revealed
changes may indirectly indicate an increase in the ac
tivity of inflammatory reactions in proportion to the in
crease in the degree of anaplasia of the cerebral tumors
and the suppression of the reactions of the adaptive im
mune response. The ratio Tr/Lf can serve as an addi
tional criterion for the degree of malignancy of cerebral
tumors. An increase in the indices characterizing the in
nate immune system, parallel with a decrease in Lf level,
may indicate a multidirectional (stimulating or suppres
sive) effect on the innate and acquired immunity of ce
rebral malignant tumors (both primary and secondary)
and related surgical treatment.
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