DISTRIBUTION CHARACTERISTICS OF COLORECTAL CANCER PATIENTS FOR GENDER AND AGE DEPENDING OF HEREDITARY PREDISPOSITION TO THE DISEASE
Keywords:
colorectal cancer, familial anamnesis, age manifestation of the disease, gender.Abstract
Aim: to analyze the distribution of males and females by the age of colorectal cancer
(CRC) onset with and without hereditary predisposition to the disease to identify
individuals at risk group. Subjects and methods: the medical records and the genealogical information of 182 patients with CRC were analyzed, including 94 males
and 88 females. «Positive» familial anamnesis for CRC was confirmed in 61 probands: 40 patients to met 1–2 of Amsterdam criteria for Lynch syndrome, 9 patients to met 3 Amsterdam criteria, 7 patients had familial adenomatous polyposis, 3 patients had familial CRC-associated inflammatory bowel diseases, 1 patient had MUTYH-associated polyposis, 1 patient had Peutz — Jeghers syndrome.
Results: age manifestation of the disease varied in regarding patient’s gender and
family history. In probands with «positive» familial anamnesis for CRC the peak
age of the disease onset was 5 years lower for both genders, compared to the age
of individuals without family history. The average age of CRC onset in probands
of both genders with «positive» familial anamnesis for this disease was the statistically significant lower, than in patients without family history. The statistically
significant difference for the average age of the CRC manifestation between males
and females without family history was revealed. Conclusion: thus, the study of
gender and age-CRC is one of the urgent problems of modern medicine. A precise
understanding age of inherited CRC manifestation of patients with CRC is important for identifying at-risk individuals, improving cancer surveillance and prevention strategies, and developing better diagnostic and therapeutic approaches.
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