MOST COMMON MOLECULAR-GENETIC CHANGES IN NON-HODGKIN’S LYMPHOMAS
Keywords:
non-Hodgkin’s lymphomas, translocations, deletions.Abstract
Summary. Non-Hodgkin’s lymphomas are heterogeneous group of malignant diseases that develop from
the lymphatic system. Non-Hodgkin’s lymphomas result from the accumulation of genetic aberrations promoting selective growth of the malignant clone. Genetic defects in lymphomas are highly specific and include
translocations, deletions, which may arise as a result of
recombination errors or errors of isotype’s shift. This article provides a brief overview of these disorders.
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