PECULIARITY OF THE EXPRESSION OF IL-10 IN CONNECTION WITH SOME FACTORS OF THE TUMOR MICROENVIRONMENT AND THE CLINICAL COURSE OF GASTRIC CANCER
Keywords:
gastric cancer, IL-10, tumor-associated macrophages, microvascular density, survival.Abstract
Summary. A study of the development of inflammatory processes of the mucous membrane, which in conditions of immune imbalance, leading to malignant transformation of the epithelium, is one of the important aspects of the pathogenesis of gastric cancer (GC). The
basis of avoidance of tumor immune surveillance and
the failure of the immune response are different mechanisms that result in the formation of immunosuppressive
background of tumor microenvironment. Perspective in
this respect is the exploring of the cytokine interleukin-10
(IL-10) and the relationship of its expression with cell
factors of tumor microenvironment particular tumor-associated macrophages (TAM) and the process of neovascularization. Objective: to investigate the features of expression of IL-10 in the tissue of GC depending on the
clinical and pathological characteristics of the tumor
process, to determine relationships between the number
of IL-10-positive (IL-10+) cells and TAM and microvascular density (MVD) in tissue GC, to assess the importance of IL-10+ cells in the clinical course of the disease. Object and methods: the study was conducted on
samples of tumor tissue of 112 patients in the primary
GC I–IV stage (pT1–4pN0–2pM0–1), immunohistochemical and statistical methods were used. Results:
the number of IL-10+ cells are more in the early stages
of the disease, as well as in hyper vascularized tumors
and tumors with a large amount of TAM. Patients with
GC, in tumors where the number of IL-10+ cells were
< 45%, TAM < 23% and MVD < 142 mcv/mm2
(with
categories T1–3), live significantly longer and have lower risk of adverse course of the disease than patients with
correspondingly higher rates. Conclusions: the number
of IL-10+ cells in the tumor is associated with protumor factors in the microenvironment (TAM and MVD),
and combined with them can be used in monitoring the
course of disease in patients with GC for correction antitumor therapy.
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