TUMOR-ASSOCIATED MACROPHAGES, FOXP3+-LYMPHOCYTES AND MICROVESSEL DENSITY IN ENDOMETRIAL CARCINOMA OF PATIENTS WITH VARIOUS MENSTRUAL STATUS
Keywords:
endometrial cancer, tumor-associated macrophages, intratumoral FOXP3+ lymphocytes, microvessel densityAbstract
Summary. Aim: to determine the relationships between the
number of tumor-associated macrophages (ТAM), intratumoral FOXP3+-lymphocytes, microvessel density (MVD)
inendometrial carcinomas and menstrual status of patients.
Object and methods: tumor tissue samples of 73 endometrial
cancer (EC) patients with clinical stage I–II aged 26 to 75
(mean age 56.3 ± 7.3 years) were investigated. Results: it
was found that 16 (21.9%) patients (aged 26 to 49 years)
had preserved menstrual function (PMF) and 57 (78.1%)
patients (aged 53 to 75 years) were postmenopausal. There
was less amount of TAM (10.3 ± 2.0%), FOXP3+-lymphocytes (23.2 ± 3.1%) and MVD (38.9 ± 1.4 vessels/mm2
)
in tumors of EC patients with PMF compared to the tumors
of patients with duration of menopause more than 10 years
(21.1 ± 2.8%, p = 0.03; 34.2 ± 4.2%, p = 0.02, and 46.1±
1.9 vessels/mm2
, p = 0.04, respectively). It was shown that
high proliferative activity in endometrial carcinomas, low degree of tumor differentiation and deep tumor invasion into
the myometrium were associated with an increased number of FOXP3+-lymphocytes, TAM and MVD. Conclusion:
it was found that endometrial carcinomas of postmenopausal patients with duration of menopause more than 10 years
are characterized by certain changes in the cellular microenvironment that are associated with indicators of more aggressive disease compared to patients with PMF that probably should be considered when determining treatment strategy for EC patients.
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