ДИАГНОСТИКА ХРОНИЧЕСКОГО МИЕЛОМОНОЦИТАРНОГО ЛЕЙКОЗА
Ключові слова:
хронический миеломоноцитарный лейкоз, диагностика, классификация ВОЗ.Анотація
Анализируются данные доступной литературы и результаты собственных
исследований авторов, касающиеся клинико-лабораторных признаков хронического миеломоноцитарного лейкоза (ХММЛ). ХММЛ является одной
из форм миелодиспластических/миелопролиферативных новообразований,
характеризующейся количеством моноцитов, превышающим 1,0•109
/л,
отсутствием слитного гена BCR-ABL1, содержанием бластных клеток
и промоноцитов в костном мозге и периферической крови, не достигающем
20%. В статье приведены цитоморфологические, иммунофенотипические
критерии диагностики ХММЛ в соответствии с пересмотренной классификацией Всемирной организации здравоохранения 2016 г. Представлены
обобщенные данные о 524 больных ХММЛ, обследованных в отделе онкогематологии Института экспериментальной патологии, онкологии и радиобиологии им. Р.Е. Кавецкого НАН Украины на протяжении 1996–2016 гг.
Посилання
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