МОЛЕКУЛЯРНІ МЕХАНІЗМИ ВИНИКНЕННЯ ПОШКОДЖЕНЬ ДНК ТА ЇХ РЕПАРАЦІЇ В НОРМАЛЬНИХ І ЗЛОЯКІСНИХ КЛІТИНАХ
DOI:
https://doi.org/10.32471/oncology.2663-7928.t-24-3-2022-g.10701Ключові слова:
клітинний цикл, пошкодження ДНК, репараціяАнотація
Реплікативний стрес є одним з вагомих факторів, який відіграє значну роль у процесах формування та прогресії багатьох типів злоякісних новоутворень, що неодноразово було продемонстровано експериментальним шляхом. Помилки в роботі полімерази, які виникають під час процесу реплікації; порушення процесів регуляції, координації та контролю над процесом реплікації; виникнення мутацій у генах, задіяних у цьому процесі тощо — усе це призводить у кінцевому підсумку до розбалансування та затримки реплікації, руйнування реплікативних вилок, виникнення порушень цілісності ланцюгів ДНК, у тому числі за рахунок появи дволанцюгових розривів. Як наслідок, усе вищезазначене зумовлює виникнення нових мутацій та хромосомних перебудов, що спричиняє пухлинну прогресію в цілому. У цій роботі проаналізовано та систематизовано молекулярні механізми, які координують процеси репарації пошкоджень ДНК у нормальних клітинах та за умов виникнення пухлинного росту.
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