ПЕРСПЕКТИВИ ВИКОРИСТАННЯ мікроРНК В ЯКОСТІ ПРЕДИКТИВНИХ МАРКЕРІВ ГОРМОНОЗАЛЕЖНОГО РАКУ МОЛОЧНОЇ ЗАЛОЗИ
DOI:
https://doi.org/10.15407/oncology.2023.04.255Ключові слова:
рак молочної залози, неоад’ювантна гормонотерапія, предиктивні маркери, мікроРНКАнотація
Гормонозалежні злоякісні новоутворення є найбільш розповсюдженою формою раку молочної залози (РМЗ) у всьому світі. Висока гетерогенність клінічних проявів та відповіді на лікування вказує на необхідність пошуку прогностичних та предиктивних маркерів для прогнозування агресивності перебігу гормонозалежного РМЗ та призначення індивідуалізованої тактики лікування. МікроРНК – це короткі молекули РНК, які приймають участь у регуляції експресії багатьох генів. Це пов’язано з тим, що мікроРНК відіграють важливу роль у модуляції процесів росту, диференціювання та формуванні метастатичного потенціалу злоякісних новоутворень різного гістогенезу, в тому числі РМЗ. МікроРНК можуть бути використані для прогнозування перебігу захворювання та вибору оптимальної тактики лікування, оскільки їх рівні можна визначати не лише в пухлинній тканині, а і в сироватці крові. Систематизація та узагальнення результатів власних досліджень, дані літератури щодо можливості використання мікроРНК в якості предиктивних маркерів гормонозалежного РМЗ вказують на перспективність використання мікроРНК для моніторингу перебігу пухлинного процесу та для визначення чутливості пухлин до неоадювантної гормональної терапії.
Посилання
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