С60 fullerene inhibits the deve lopment of inflammation and alteration of hematopoiesis in experimental chronic cholangitis
DOI:
https://doi.org/10.15407/dopovidi2019.12.091Keywords:
C60 fullerene, erythrocytes, experimental chronic cholangitis, leukocytes, plateletsAbstract
The effect of C60 fullerene on the state of blood cells under experimental chronic cholangitis is studied. Intraperitoneal administration of C60 fullerene inhibits the development of inflammation, which is confirmed by a decrease in the content of eosinophilic granulocytes and lymphocytes, involves neutrophil granulocytes in the C60 accumulation, causing neutrophilia in blood, and enhances the manifestations of anemia. Oral application of C60 inhibits the development of inflammation without increasing the number of neutrophilic granulocytes in blood and partly reduces the manifestations of anemia by maintaining the amount of erythrocytes in blood, suggesting its less toxicity.
Downloads
References
Stoika, R. S., Prylutskyy, Yu. I., Naumovets, A. G., Bilyy, R. O. & Blume, Y. B. (2017). Multifunctional nano materials for biology and medicine: molecular design, synthesis and application. Kyiv: Naukova Dumka (in Ukrainian).
Prylutska, S. V., Grynyuk, I. I., Matyshevska, O. P., Prylutskyy, Y. I., Ritter, U. & Scharff P. (2008). Antioxidant properties of C60 fullerenes in vitro. Fuller. Nanotub. Carbon Nanostruct., 6, pp. 698-705. Doi: https://doi.org/10.1080/15363830802317148
Prylutska, S. V., Didenko, G. V., Kichmarenko, Yu. M., Kruts, O. О., Potebnya, G. P., Cherepanov, V. V. & Prylutskyy Yu. I. (2014). Effect of C60-fullerene, doxorubicin and their complex on tumor and normal cells of the line mice BALB/с. Biotechnol. Acta, 7, No. 1, pp. 60-65 (in Ukrainian).
Prylutskyy, Y., Bychko, A., Sokolova, V., Prylutska, S., Evstigneev, M., Rybalchenko, V., Epple, M. & Scharff P. (2016). Interaction of C60 fullerene complexed to doxorubicin with model bilipid membranes and its upta ke by HeLa cells. Mater. Sci. Eng. C Mater. Biol. Appl., 59, pp. 398-403. Doi: https://doi.org/10.1016/j.msec.2015.10.049
Lynchak, O. V., Prylutskyy, Y. I., Rybalchenko, V. K., Kyzyma, O. A., Soloviov, D., Kostjukov, V. V., Evstigneev, M. P., Ritter, U. & Scharff, P. (2017). Comparative analysis of the antineoplastic activity of C60 fullerene with 5-fluorouracil and pyrrole derivative in vivo. Nanoscale Res. Lett., 12, No. 8, pp. 1-6. Doi: https://doi.org/10.1186/s11671-016-1775-0
Prylutska, S. V., Grebinyk, A. G., Lynchak O. V., Byelinska I. V., Cherepanov, V. V., Tauscher, E., Matyshevska, O. P., Prylutskyy, Y. I., Rybalchenko, V. K., Ritter, U. & Frohme, M. (2019). In vitro and in vivo toxicity of pristine C60 fullerene aqueous colloid solution. Fuller., Nanotub. Carbon Nanostruct., 27, Iss. 9, pp. 715-728. Doi: https://doi.org/10.1080/1536383X.2019.1634055
Byelinska, I. V., Kuznietsova, H. M., Dziubenko, N. V., Lynchak, O. V., Rybalchenko, T. V., Prylutskyy, Yu. I., Kyzyma, O. A., Ivankov, O., Rybalchenko, V. K. & Ritter, U. (2018). Effect of C60 fullerenes on the intensity of colon damage and hematological signs of ulcerative colitis in rats. Mater. Sci. Eng. C. Mater. Biol. Appl., 93, pp. 505-517. Doi: https://doi.org/10.1016/j.msec.2018.08.033
Kuznietsova, H. M., Lynchak, O. V., Dziubenko, N. V., Osetskyi, V. L., Ogloblya, O. V., Prylutskyy, Yu I., Rybalchenko, V. K., Ritter, U. & Scharff, P. (2019). Water-soluble C60 fullerenes reduce manifestations of acute cholangitis in rats. Appl. Nanosci., 9, Iss. 5, pp. 601-608. Doi: https://doi.org/10.1007/s13204-018-0700-5
Tabibian, J. H., Ali, A. H. & Lindor, K. D. (2018). Primary sclerosing cholangitis, Part 1: epidemiology, etiopathogenesis, clinical features, and treatment. Gastroenterol. Hepatol., 14, No. 5, pp. 293-304.
Malakhova, I. G., Shklyaev, A. E. & Utkin, I. Y. (2016). Acute cholangitis complicated by biliary sepsis: clinical case with a favorable outcome. Arhiv vnutrennej mediciny, 60, No. 4, pp. 65-69. (in Russian). Doi: https://doi.org/10.20514/2226-6704-2016-6-4-65-69
Naqvi, S., Hasan, S. A., Khalid, S., Abbass, A. & Albors-Mora, M. (2018). A unique triad: ulcerative colitis, primary sclerosing cholangitis, and autoimmune hemolytic anemia. Cureus, 10, No. 1, e2068. Doi: https://doi.org/10.7759/cureus.2068
Tsuneyama, K., Baba, H., Morimoto, Y., Tsunematsu, T. & Ogawa, H. (2017). Primary biliary cholangitis: its pathological characteristics and immunopathological mechanisms. J. Med. Invest., 64, No. 1.2, pp. 7-13. Doi: https://doi.org/10.2152/jmi.64.7
Gkamprela, E., Deutsch, M. & Pectasides, D. (2017). Iron deficiency anemia in chronic liver disease: etiopathogenesis, diagnosis and treatment. Ann. Gastroenterol., 30, No. 4, pp. 405-413. Doi: https://doi.org/10.20524/aog.2017.0152
Fickert, P., Pollheimer, M. J., Beuers, U., Lackner, C., Hirschfield, G., Housset, C., Keitel, V., Schramm, С., Marschall, H.U., Karlsen, T.H., Melum, E., Kaser, A., Eksteen, B., Strazzabosco, M., Manns, M. & Trauner, M. (2014). Characterization of animal models for primary sclerosing cholangitis (PSC). J. Hepatol., 60, pp. 1290-1303. Doi: https://doi.org/10.1016/j.jhep.2014.02.006
Ritter, U., Prylutskyy, Yu. I., Evstigneev, M. P., Davidenko, N. A., Cherepanov, V. V., Senenko, A. I., Marchenko, O. A. & Naumovets, A. G. (2015). Structural features of highly stable reproducible C60 fullerene aqueous colloid solution probed by various techniques. Fuller., Nanotub., Carbon Nanostruct., 23, No. 6, pp. 530-534. Doi: https://doi.org/10.1080/1536383X.2013.870900
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Reports of the National Academy of Sciences of Ukraine
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
