Hepatoprotective effect of protein kinase inhibitor 1-(4-Cl-benzyl)-3-chloro-4-(CF3-phenylamino)-1H-pyrrole-2,5-dione on rats' acute cholangitis

Authors

  • H.M. Kuznietsova Taras Shevchenko National University of Kyiv
  • N.V. Dziubenko Taras Shevchenko National University of Kyiv
  • O.V. Lynchak Taras Shevchenko National University of Kyiv
  • O.I. Tykhoniuk Taras Shevchenko National University of Kyiv
  • D.S. Milokhov Taras Shevchenko National University of Kyiv
  • O.V. Khilya Taras Shevchenko National University of Kyiv
  • V.K. Rybalchenko Taras Shevchenko National University of Kyiv

DOI:

https://doi.org/10.15407/dopovidi2018.05.083

Keywords:

1-(4-Cl-benzyl)-3-chloro-4-CF3-phenylamino)-1H-pyrrole-2;5-dione, acute cholangitis, prednisolone

Abstract

The effect of protein kinase inhibitor 1-(4-Cl-benzyl)-3-chloro-4-(CF3-phenylamino)-1H-pyrrole-2,5-dione (MI-1) on liver states of rats experienced α-naphthyl isothiocyanate-induced acute cholangitis in comparison with an tiinflammatory drug prednisolone is investigated. Both prednisolone and MI-1 attenuated cholangitis manifestations and partially restored the liver functional activity: prednisolone decreased serum transaminases acti vities, while MI-1 leveled direct and total bilirubin, which could indicate its effectiveness for correcting the investigated pathology.

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References

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Published

15.05.2024

How to Cite

Kuznietsova, H., Dziubenko, N., Lynchak, O., Tykhoniuk, O., Milokhov, D., Khilya, O., & Rybalchenko, V. (2024). Hepatoprotective effect of protein kinase inhibitor 1-(4-Cl-benzyl)-3-chloro-4-(CF3-phenylamino)-1H-pyrrole-2,5-dione on rats’ acute cholangitis . Reports of the National Academy of Sciences of Ukraine, (5), 83–90. https://doi.org/10.15407/dopovidi2018.05.083

Issue

No. 5 (2018): Reports of the National Academy of Sciences of Ukraine

Section

Biology

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