Comparison of the effectivenesses of a new targeted compound maleimide derivative and cytostatic 5-fluorouracil in chemo-induced colon cancer in rats
DOI:
https://doi.org/10.15407/dopovidi2014.02.142Keywords:
chemo-induced cancer, colon of rats, effectivenesses, targeted compound maleimideAbstract
The maleimide derivative 1-(4-Cl-benzyl)-3-Cl-4-(CF3-phenylamino)-1H-pyrrol-2,5-dione (MI-1) is quite efficient in comparison with 5-fluorouracil in rat chemo-induced colon carcinogenesis. MI-1 is a promising compound for the further research and can become a basis for developing new targeted anticancer drugs.
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