Effect of the complex of C60 fullerene with doxorubicin on tumor cells in vitro and in vivo
DOI:
https://doi.org/10.15407/dopovidi2014.06.146Keywords:
complex of C60 fullerene, doxorubicin, tumor cellsAbstract
A technological scheme for preparing a stable aqueous solution of C60 fullerene with an antibiotic doxorubicin (Dox) of the anthracycline row is proposed. The toxic effect of the C60+Dox complex on cells of Ehrlich ascites carcinoma, leukemia L1210, and Lewis lung carcinoma is demonstrated. Its antitumor effect on Lewis lung carcinoma in vivo was also shown. Thus, a high efficiency of the C60+Dox complex in the anticancer therapy is postulated.
Downloads
References
Matyshevska O. P., Prylutska S. V., Grynyuk I. I. Biotekhnologiia, 2010, 3, No. 1: 18–26 (in Ukrainian).
Burlaka A. P., Sidorik E. P., Prylutska S. V. et al. Exp. Oncol., 2004, 26: 326–327.
Prylutska S. V., Grynyuk I. I., Matyshevska O. P. et al. Fullerenes Nanotubes Carbon Nanostruct., 2008, 16: 698–705. https://doi.org/10.1080/15363830802317148
Scharff P., Risch K., Carta-Abelmann L. et al. Carbon., 2004, 42: 1203–1206. https://doi.org/10.1016/j.carbon.2003.12.053
Prylutska S. V., Matyshevska O. P., Grynyuk I. I. et al. Mol. Cryst. Liq. Cryst., 2007, 468: 265–274. https://doi.org/10.1080/15421400701230105
Prylutska S., Bilyy R., Overchuk M. et al. J. Biomed. Nanotechnol., 2012, 8: 522–527. https://doi.org/10.1166/jbn.2012.1404
Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes. In: Cataldo F., Da Ros T. (Ed.). Ser. Carbon Materials: Chemistry and Physics. Vol. 1. Berlin: Springer, 2008.
Prylutska S. V., Burlaka A. P., Prylutsky Yu. I. et al. Exp. Oncol., 2011, 33: 162–164.
Andrievsky G., Klochkov V., Derevyanchenko L. Fullerenes Nanotubes Carbon Nanostruct., 2005, 13: 363–376. https://doi.org/10.1080/15363830500237267
Prylutska S. V., Grynyuk I. I., Grebinyk S. M. et al. Mat.-wiss. u. Werkstofftech., 2009, 40: 238–241. https://doi.org/10.1002/mawe.200900433
Rouse J. G., Yang J., Barton A. R., Monteiro-Reviere N. A. Toxicol. In Vitro, 2006, 20: 1313–1320. https://doi.org/10.1016/j.tiv.2006.04.004
Hrelia S., Fiorentini D., Maraldi T. et al. Biochem. Biophys. Acta., 2002, 64: 139– 145.
Evstigneev M. P., Buchelnikov A. S., Voronin D. P. et al. Chem. Phys. Chem., 2013, 14: 568–578. https://doi.org/10.1002/cphc.201200938
Carmichael J., De Graff W. G., Gazdar A. F. et al. Br. J. Cancer., 1991, 63: 75–83. https://doi.org/10.1038/bjc.1991.16
Gharbi N., Pressac M., Hadchouel M. et al. Nano Lett., 2005, 5: 2578–2585. https://doi.org/10.1021/nl051866b
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Reports of the National Academy of Sciences of Ukraine
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
