CARBON SILICON-CONTAINING COMPOSITE MATRIX FOR THE DEVELOPMENT OF ADVANCED BACTERICIDAL APPLICATION AGENTS IN SURGERY
DOI:
https://doi.org/10.15407/dopovidi2024.05.026Keywords:
carbon fiber composite material, modification of carbon fiber composite matrix with silicon dioxide, biomedical propertiеsAbstract
The technology of obtaining carbon fiber composite matrix VVCCM with silicon dioxide content for medical purposes is developed and the algorithm of its production is described. The conditions of the main stages of the technological process of VVCCM manufacturing are established. The influence of structure-forming additive on the conditions of formation of sol and structurally bonded layer of silicon dioxide in the developed material has been investigated. The parameters of the porous structure were studied by the benzene vapor moisture absorption method. The microstructure of surface and near-surface layers containing silicon dioxide in the composite matrix samples was investigated using a scanning electron microscope Mira 3 LMU (“Tescan”, Czech Republic), which made it possible to determine the location of the silicon dioxide layer in the composite structure, as well as its individual surface inclusions. The phenomenon of silicon dioxide aggregation into finely dispersed fiber-like structures after 100% combustion of carbon component in the process of ash formation at T = 1073 K has been found. The shape and size of silicon dioxide particles as well as their surface morphology were determined. Using the method of energy dispersive X-ray analysis and analytical chemistry methods to determine the chemical composition of composite matrix samples, it is proved that mineral inclusions on the surface of carbon fiber composite matrix microfibers are represented by silicon and silicon dioxide particles. The novelty of the developed technology lies in the discovery of an additional structural component in the composition of VVCKM, which allows us to refer it to a new class of carbon composite materials. In the composite matrix of VVCCM obtained by us, healing and bactericidal properties can be provided due to the presence of SiO2 particles of ~100—500 nm in the structure of the material, which are able to promote cellular regeneration of the wound surface and destroy bacterial cells. This will allow to use VVKKM as bactericidal application agents in the treatment of purulent and complicated bacterial lesions both in the field and in hospital surgery.
Downloads
References
Kononko, I. V., Sergieiev, V. P., Klipov, V. D. & Kononko, N. V. (2022). Review of the basic requirements for the quality of medical materials. Applied aspects. Visn. Nac. Acad. Nauk Ukr., No. 9, pp. 50-63 (in Ukrainian). https://doi.org/10.15407/visn2022.09.050
Shen, Z., Cai, N., Xue, Y., Chan, V., Yu, B., Wang, J., Song, H., Deng, H. & Yu, F. (2019). Engineering sustainable antimicrobial release in silica-cellulose membrane with CaCO3-aided processing for wound dressing application. Polymers, 11, No. 5, 808. https://doi.org/10.3390/polym11050808
Zulkiflee, I., Masri, S., Zawani, M., Salleh, A., Amirrah, I. N., Wee, M. F. M. R., Yusop, S. M. & Fauzi, M. B. (2022). Silicon-based scaffold for wound healing skin regeneration applications: a concise review. Polimers, 14, No. 19, 4219. https://doi.org/10.3390/polym14194219
Fan, C., Xu, Q., Hao, R., Wang, C., Que, Y., Chen, Y., Yang, C. & Chang, J. (2022). Multi-functional wound dressings based on silicate bioactive materials. Biomaterials, 287, 121652. https://doi.org/10.1016/j. biomaterials.2022.121652
Öri, F., Dietrich, R., Ganz, C., Dau, M., Wolter, D., Kasten, A., Gerber, T. & Frerich, B. (2017). Silicon-dioxide− polyvinylpyrrolidone as a wound dressing for skin defects in a murine model. J. Cranio-Maxillofac. Surg., 45, Iss. 1, pp. 99-107. https://doi.org/10.1016/j.jcms.2016.10.002
Mesa, M. & Becerra, N. Y. (2021). Silica/protein and silica/polysaccharide interactions and their contributions to the functional properties of derived hybrid wound dressing hydrogels. Int. J. Biomater., 6857204. https://doi. org/10.1155/2021/6857204
Mokienko, A. V. (2020). Silicon in water. Hygienic and medical-biological aspects. Odessa: Fenix (in Russian).
Chuyko, A. A. (Ed.). (2003). Medicinal chemistry and clinical application of silicon dioxide Kyiv: Naukova Dumka (in Russian).
Zare, M., Ghomi, E. R., Venkatraman, P. D. & Ramakrishna, S. (2021). Silicone-based biomaterials for biomedical applications: Antimicrobial strategies and 3D printing technologies. J. Appl. Polymer Sci., 138, Iss. 38. https://doi.org/10.1002/app.50969
Bandas, I. A., Kulytska, M. I., Yaroshenko, T. Ya. & Korda, M. M. (2017). Silicone dioxide nano-particles enhance toxicity of lead on oxidative and nitro-oxidative stress. Medychna ta klinichna khimiia, 19, No. 3, pp. 48-53 (in Ukrainian). https://doi.org/10.11603/mcch.2410-681X.2017.v0.i3.8206
Shcherbytska, O. V., Garbuz, V. V., Klipov, V. D., Sergeyev, V. P., Kononko, I. V., Klevtsov, V. M. & Kononko, N. V. (2010). Study of processes of formation of carbon nanostructures during thermal destruction and carbonization of hydrated cellulose fibers. Part II. Concentration of paramagnetic centers and mechanical properties of pyrolysis products of hydrocellulose fibers and identification of carbon nanofibers. Nanostrukturnoe materialovedenie, No. 4, pp. 39-44 (in Ukrainian).
Shcherbytska, O. V., Garbuz, V. V., Klipov, V. D., Sergeyev, V. P., Kononko, I. V., Klevtsov, V. M., Lobunets, T. F.
& Uvarova, I. V. (2010). Study of processes of formation of carbon nanostructures during thermal destruction and carbonization of hydrated cellulose fibers. Part I. Study of the composition and physico-chemical properties of gaseous and solid products of the thermal destruction of cellulose. Nanostrukturnoe materialovedenie, No. 2, pp. 24-31 (in Ukrainian).
Kononko, I. V., Boshytska, N. V., Sergeev, V. P., Klipov, V. D. & Kononko, N. V. (2021). Carbon nanostructured material for multiple protective masks. Dopov. Nac. akad. nauk Ukr., No. 6, pp. 78-86 (in Ukrainian). https:// doi.org/10.15407/dopovidi2021.06.078
Raksha-Slyusareva, O. A., Pimonenko, M. Yu. & Slyusarev, O. A. (2015). New carbon fiber sorbents adsorption properties to the pathogens mikroorganizm in model experiments. Profilaktychna medytsyna, No. 1-2, pp. 56- 59 (in Ukrainian). https://doi.org/10.61948/prevmed
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Reports of the National Academy of Sciences of Ukraine
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
