СТРЕС-ІНДУКОВАНІ ЗМІНИ ПРОТИПУХЛИННОГО ІМУНІТЕТУ
DOI:
https://doi.org/10.15407/oncology.2025.03.161Ключові слова:
стрес, рак, катехоламіни, глюкокортикоїди, мікроелементи, протипухлинний імунітетАнотація
Результати експериментальних та клінічних досліджень свідчать про значний модифікуючий вплив стресу на функціонування як окремих фізіологічних систем, так і організму в цілому, що не тільки підвищує ризик виникнення злоякісних новоутворень, а й може негативно впливати на результати лікування пацієнтів з цією патологією. В оглядовій статті авторами представлено аналіз даних сучасної наукової літератури щодо взаємозв'язку між стресом і онкогенезом, представлені стрес-індуковані зміни вмісту основних мікроелементів (мідь, залізо, цинк, ферум, кальцій), які відіграють ключову роль у багатьох біологічних процесах. Значна увага приділяється змінам функцій імунокомпетентних клітин, що входять до складу пухлинного мікрооточення та опосередковують реалізацію протипухлинної імунної відповіді, в умовах гострого та хронічного стресу.
Посилання
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