Синтез нових оксоімідазолідинових сульфонамідів з протипухлинною активністю

О.V.  Shablykin; Y.E.  Kornii; V.S.  Brovarets; O.V.  Shablykina; V.P.  Khilya

doi:10.15407/dopovidi2019.01.079

Authors

О.V. Shablykin Institute of Bioorganic Chemistry and Petrochemistry V.P. Kukhar
Y.E. Kornii Institute of Bioorganic Chemistry and Petrochemistry V.P. Kukhar
V.S. Brovarets Institute of Bioorganic Chemistry and Petrochemistry V.P. Kukhar
O.V. Shablykina Taras Shevchenko National University of Kyiv
V.P. Khilya Taras Shevchenko National University of Kyiv

DOI:

https://doi.org/10.15407/dopovidi2019.01.079

Keywords:

anticancer activity, heterocyclization, N-substituted (Z)-N’-(5-(dichloromethylene)-2-oxoimidazolidin-4-ylidene)sulfamides

Abstract

By the interaction of 2-amino-3,3-dichloroacrylonitrile and chlorosulphonyl isocyanate, (Z)-(5-(dichloromethylene)-2-oxoimidazolidin-4-ylidene)sulfamoyl chloride reacting easily with the excess of an aliphatic amine to form new N-substituted (Z)-N’-(5-(dichloromethylene)-2-oxoimidazolidin-4-ylidene)sulfamides is obtained. According to the National Cancer Institute (USA) examinations, two of the six synthesized amides showed a high anticancer activity.

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References

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