Evolutionary transition-transversion bias by the example of the cytb gene of palearctic Muridae (Rodentia) and Vespertilionidae (Chiroptera)
DOI:
https://doi.org/10.15407/dopovidi2023.02.093Keywords:
evolutionary ts/tv rate bias, Muridae, Vespertilionidae, molecular evolution, molecular clockAbstract
A comparative analysis of the features of the transition-transversion bias of the nucleotide sequence of the cytb gene in microbats (Vespertilionidae, Chiroptera) and mice (Muridae, Rodentia) shows both general regularities and certain family-level features. A common feature of the two families is the fact of the sharp predominance of transitions over transversions at the early stages of the evolutionary process, followed by the equalization of the ts/tv-displace- ment at the species and genus levels of divergences, as well as the fact that the increase in the frequency of transitions in phyletic lineages is gradual, and the transition is intermittent. At the same time, the levels of spontaneous mutations and evolutionary drift, as well as the rate of ts/tv drift compensation, are specific to families. These circumstances do not make it possible to obtain comparable estimates of divergence in different phyla and cause insurmountable difficulties in creating a universal formula for molecular clocks.
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References
Zuckerkandl, E. & Pauling, L. (1962). Molecular disease, evolution, and genic heterogeneity. In Kasha, M. & Pullman, B. (Ed.). Horizons in biochemistry (pp. 189-225). New York: Academic Press.
Pesole, G., Gissi, C., De Chirico, A. & Saccone, C. (1999). Nucleotide substitution rate of mammalian mito- chondrial genomes. J. Mol. Evol., 48, No. 4, pp. 427-434. https://doi.org/10.1007/PL00006487
Kumar, S. (2005). Molecular clocks: four decades of evolution. Nat. Rev. Genet., 6, No. 8, pp. 654-662. https://doi.org/10.1038/nrg1659
Huang, S. (2008). The genetic equidistance result of molecular evolution is independent of mutation rates. J. Comp. Sci. Syst. Biol., 1, pp. 92-102. https://doi.org/10.4172/jcsb.1000009
Ho, S. Y. W. & Duchene, S. (2014). Molecular-clock methods for estimating evolutionary rates and times- cales. Mol. Ecol., 23 (24), pp. 5947-5965. https://doi.org/10.1111/mec.12953
Collins, D. W. & Jukes, T. H. (1994). Rates of transition and transversion in coding sequences since the hu- man-rodent divergence. Genomics, 20, Iss. 3, pp. 386-396. https://doi.org/10.1006/geno.1994.1192
Belle, E. M. S., Piganeau, G., Gardner, M. & Eyre-Walker, A. (2005). An investigation of the variation in the transition bias among various animal mitochondrial DNA. Gene, 355, Iss.1, pp. 58-66. https://doi.org/10.1016/j.gene.2005.05.019
Duchene, S., Ho, S. Y. & Holmes, E. C. (2015). Declining transition/transversion ratios through time reveal limitations to the accuracy of nucleotide substitution models. BMC Evol. Biol., 15, 36. https://doi.org/10.1186/s12862-015-0312-6
Fitch, W. M. (1967). Evidence suggesting a non-random character to nucleotide replacements in naturally occurring mutations. J. Mol. Biol., 26, Iss. 3, pp. 499-507. https://doi.org/10.1016/0022-2836(67)90317-8
Kumar, S. (1996). Patterns of nucleotide substitution in mitochondrial protein coding genes of vertebrates. Genetics, 143, Iss. 1, pp. 537-48. https://doi.org/10.1093/genetics/143.1.537
Ebersberger, I., Metzler, D., Schwarz, C. & Pääbo, S. (2002). Genomewide comparison of DNA sequences between humans and chimpanzees. Am. J. Hum. Genet., 70, Iss. 6, pp. 1490-1497. https://doi.org/10.1086/340787
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