Synthesis of new oxoimidazolidine sulfonamides with anticancer activity

Authors

  • О.V. Shablykin Institute of Bioorganic Chemistry and Petrochemistry V.P. Kukhar
  • Y.E. Kornii Institute of Bioorganic Chemistry and Petrochemistry V.P. Kukhar
  • V.S. Brovarets Institute of Bioorganic Chemistry and Petrochemistry V.P. Kukhar
  • O.V. Shablykina Taras Shevchenko National University of Kyiv
  • V.P. Khilya Taras Shevchenko National University of Kyiv

DOI:

https://doi.org/10.15407/dopovidi2019.01.079

Keywords:

anticancer activity, heterocyclization, N-substituted (Z)-N’-(5-(dichloromethylene)-2-oxoimidazolidin-4-ylidene)sulfamides

Abstract

By the interaction of 2-amino-3,3-dichloroacrylonitrile and chlorosulphonyl isocyanate, (Z)-(5-(dichloromethylene)-2-oxoimidazolidin-4-ylidene)sulfamoyl chloride reacting easily with the excess of an aliphatic amine to form new N-substituted (Z)-N’-(5-(dichloromethylene)-2-oxoimidazolidin-4-ylidene)sulfamides is obtained. According to the National Cancer Institute (USA) examinations, two of the six synthesized amides showed a high anticancer activity.

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References

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Retrieved from http://dtp.cancer.gov

Retrieved from https://dtp.cancer.gov/discovery_development/nci-60/default.htm

Published

28.03.2024

How to Cite

Shablykin О. ., Kornii, Y. ., Brovarets, V. ., Shablykina, O. ., & Khilya, V. . (2024). Synthesis of new oxoimidazolidine sulfonamides with anticancer activity . Reports of the National Academy of Sciences of Ukraine, (1), 79–85. https://doi.org/10.15407/dopovidi2019.01.079

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