Efficient preparative synthesis of isoflavones with the amide function
DOI:
https://doi.org/10.15407/dopovidi2015.09.079Keywords:
2-(2-(morpholin-4-ylcarbonyl)phenyl)-1-(2-hydroxyphenyl)ethanones, 3-[2-(morpholin-4-ylcarbonyl)phenyl]-4H-chromen-4-ones, N; N-dimethylformamide dimethylacetalAbstract
The reactivity of amides of 2-hydroxydezoxybenzoine-2′-carboxylic acids is investigated. A convenient method to obtain isoflavones with a carboxamide group is developed, using the interaction 2-[2-(morpholin-4-ylcarbonyl)phenyl]-1-(2-hydroxyphenyl)ethanones with DMFDMA. Acetylation of 2-[2-(morpholin-4-ylcarbonyl)phenyl]-1-(2-hydroxyphenyl)ethanones in basic solutions passes to the cyclization to form an isocoumarin system.
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