РОЛЬ ПРОТЕЇНА RB У ПІДТРИМЦІ СТОВБУРОВОСТІ КЛІТИН
DOI:
https://doi.org/10.15407/oncology.2023.04.245Ключові слова:
ротеїн RB, взаємодіючі із RB протеїни, стовбуровість, плюрипотентні клітини, клітинний цикл, транскрипційні фактори.Анотація
В огляді систематизовано дані літератури та результати власних досліджень, присвячені ролі білка ретинобластоми (RB) у життєдіяльності стовбурових плюрипотентних клітин (СК). Висвітлено питання щодо впливу протеїну RB на проходження клітинного циклу та розвиток патологічних станів, участь цього протеїну у контролі диференціювання клітин певного гістогенезу, а також існуючі дані про порушення епігенетичної регуляції експресії специфічних для СК генів за рахунок взаємодії їх продуктів з протеїном RB. Наш огляд може бути корисним для подальшого вивчення та розуміння властивостей СК, а також ефективності їх використання у медичній практиці.
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