The effect of the low molecular weight fraction (up to 10 kDa) of human cord blood on the structural and functional properties of erythrocytes after hypothermic storage
DOI:
https://doi.org/10.15407/dopovidi2019.03.084Keywords:
erythrocytes, hypothermic storage, morphology, recovery, saturationAbstract
The “rejuvenating” effect of the low molecular weight fraction cord blood (below 10 kDa) on the erythrocyte morphology and the affinity of hemoglobin to oxygen is investigated. The efficiency of using the rehabilitating media containing this fraction to restore the structural and functional properties of red blood cells based on cord blood is shown.
Downloads
References
VinogradeFinkel, F.R., Derviz, G.V., Andreeva, A.G. et al. (1974). Metabolic activity and respiratory function of blood preserved on acidic glucosecitrate solutions and ways to improve these solutions. Problemy gematologii i perelivanija krovi, No. 7, pp. 3-9 (in Russian).
Rumyantsev, A.G. & Agranenko, V.A. (1997). Clinical transfusiology. Moscow: GEOTAR MEDITsINA (in Russian).
Valeri, C. (1976). Blood banking and the use of frozen blood products. Cleveland: CRS Press.
Gulevsky, O.K., Akhatova, Yu.S., Sysoev, À.À. & Sysoeva, I.V. (2014). Stimulating effect of a lowmolecular fraction cord blood on the energy metabolism in leukocytes. Dopov. Nac. acad. nauk Ukr., No. 7, pp. 152-157 (in Russian). doi: https://doi.org/10.15407/dopovidi2014.07.152
Gulevsky, O.K., Mo³seeva, N.M., Gorina, O.L., Akhatova, J.S., Lavrik, A.A. & Trifonova, A.V. (2014). The influence of lowmolecular fraction from cord blood (below 5 kDa) on functional and biochemical parameters of cells in vitro. Ukr. Biochem. J., No. 6, pp. 167-174 (in Ukranian). doi: https://doi.org/10.15407/ubj86.06.167
Pat. 69652 Ukraine, IPC A 61 K 35/14. The method of obtaining low molecular weight fraction from cord blood of cattle, Gulevsky, Î.Ê., Mo³seeva, N.M., Abakumova, O.S., Schenyavsky, I.Y., Nikolchenko, A.Yu., Gorina, O.L., Publ. 10.05.2012.
Menshikov, V.V. (1999). Clinical laboratory analytics. Moscow: LabirintRAMLD (in Russian).
Pupkova, V.I. (2001). Determination of hemoglobin in the blood. Koltsovo (in Russian). Retrieved from http://www.technomedica.ru/site_files/docs/books/2Pup.pdf
Wood, T.E., Daliti, S., Simpson, C.D., Hurren, R., Mao, X., Saiz, F.S., Gronda, M., Eberhard, Y., Minden, M.D., Bilan, P.J., Klip, A., Batey, R.A. & Schimmer, A.D. (2008). A novel inhibitor of glucose uptake sensitizes cells to FASinduced cell death. Mol. Cancer Ther., 7, No. 11, pp. 3546-3555. doi: https://doi.org/10.1158/1535-7163.MCT-08-0569
Blodgett, D.M., Graybill, C. & Carruthers, A. (2008). Analysis of the glucose transporter and structural dynamics. J. Biol. Chem., 283, No. 52, pp. 36416-36424. doi: https://doi.org/10.1074/jbc.M804802200
Gulevsky, A.K. & Zharkova, E.E. (2016). Restoration of the morphological and functional properties of erythrocytes in donated blood after hypothermic storage. Dopov. Nac. acad. nauk Ukraine, No. 3, pp. 93-97 (in Russian). doi: https://doi.org/10.15407/dopovidi2016.03.093
Lutsenko, M.T. & Nadtochy, E.V. (2009). Morphofunctional changes in erythrocytes of peripheral blood at hypoxia in patients with bronchial asthma. Byulleten fiziologii i patologii dyihaniya, No. 31, pp. 12-15 (in Russian).
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Reports of the National Academy of Sciences of Ukraine

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

