Influence of bisoprolol and nebivolol on the spectrum of substituted amino acids in blood plasma of patients with stable angina
DOI:
https://doi.org/10.15407/dopovidi2021.03.104Keywords:
ß-blockers, bisoprolol, nebivolol, amino acidsAbstract
For many years, ß-blockers have been used to treat patients with coronary heart disease. In patients with stable angina, the effect of ß-blockers on the amino acid spectrum of blood serum has been studied. Its violation is considered as one of the pathogenetic links in the development of atherosclerosis. The study showed a more efficient action of nebivolol compared to bisoprolol on the amino acid imbalance. In patients with stable angina against the background of antianginal therapy, which included bisoprolol and nebivolol, there was a significant decrease in the total amount of amino acids, the amount of essential amino acids, and the amount of essential amino acids compared to the treatment. Against the background of the nebivolol treatment, there is a positive dynamics of sulfur-containing amino acids (methionine level was maintained, taurine level was significantly increased, cystine level was normalized), isoleucine level was normalized, which indirectly indicates cardioprotective and angiprotective effect of nebivolol.
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Vinereanu, D., Gherghinescu, C., Ciobanu, A. O., Magda, S., Niculescu, N., Dulgheru, R., Dragoi, R., Lautaru, A., Cinteza, M. & Fraser, A. G. (2011). Reversal of subclinical left ventricular dysfunction by antihypertensive treatment: a prospective trial of nebivolol against metoprolol. J. Hypertens., 29, No. 4, pp. 809-817. https://doi. org/10.1097/HJH.0b013e3283442f37
Waehre, T., Halvorsen, B.,. Damås, J. K., Yndestad, A., Brosstad, F., Gullestad, L., Kjekshus, J., Frøland, S. S. & Aukrust, P. (2002). Inflammatory imbalance between IL-10 and TNFalpha in unstable angina potential plaque stabilizing effects of IL-10. Eur. J. Clin. Invest., 32, pp. 803-810. https://doi.org/10.1046/j.1365-2362. 2002.01069.x
Girin, V. V. (2009). Assessment of the pathological condition in type 1 diabetes by determining the fatty acid spectrum of salivary lipids. Nauk. visnyk Nats. med. un-tu im. O.O. Bohomoltsia, No. 2/3, pp. 93-96 (in Ukrainian).
Lutai, M. I., Bugayenko, V. V., Moiseyenko, O. I., Mushtenko, L. O. & Slobodskyi, V. A. (2011). The value of L-arginine in the treatment of patients with cardiovascular pathology. Ukr. cardiol. zhurn., No. 4, p. 96-107 (in Ukrainian).
Athyros, V. G., Kakafika, A. I., Tziomalos, K., Karagiannis, A. & Mikhailidis, D. P. (2009). Pleiotropic eff ects of statins — clinical evidence. Curr. Pharm. Des., 15, No. 5, pp. 479-489. https://doi. org/10.2174/ 138161209787315729
Li, Y., Arnold, J. M. O., Pampillo, M., Babwah, A. V. & Peng, T. (2009). Taurine prevents cardiomyocyte death by inhibiting NADPH oxidase-mediated calpain activation. Free Radic. Biol. Med., 46, No. 1, pp. 51-61. https://doi.org/10.1016/j.freeradbiomed.2008.09.025
Lyzogub, V. G., Zavalskaya, T. V., Bogdan, V. V. & Zhornichenko, D. M. (2015). Blood plasma nonessential aminoacids of stable and unstable stenocardia patients. Dopov. Nac. akad. nauk Ukr., No. 6, pp. 167-174 (in Ukrainian). https://doi.org/10.15407/dopovidi2015.06.167
Zavalska, T. V. (2015). Blood plasma essential aminoacids of stable and unstable stenocardia patients. Dopov. Nac. akad. nauk Ukr., No. 5, pp. 173-177 (in Ukrainian). https://doi.org/10.15407/dopovidi2015.05.173
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