Effects of paclitaxel and nuclear factor NF-κB inhibitor in thyroid cancer tumors in vivo
DOI:
https://doi.org/10.15407/dopovidi2014.05.164Keywords:
inhibitor, nuclear factor, paclitaxel, thyroid cancer tumorsAbstract
Nuclear factor kappa B (NF-κB) inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) enhances the therapeutic effect of paclitaxel on tumors formed by the xenotransplantation of anaplastic thyroid carcinoma FRO cells. In animals treated with paclitaxel and NF-κB inhibitor, a reduction in the tumor volume was observed, which is significantly different from the effects of each of the compounds in particular. Thus, the combined use of paclitaxel and NF-κB inhibitor is a promising strategy for further preclinical studies for developing the new chemotherapeutic approaches for the anaplastic thyroid cancer treatment.
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