Synthesis of new chloroaryl-containing sulfonylamides of isoxazole series via ring-closing metathesis
DOI:
https://doi.org/10.15407/dopovidi2015.10.064Keywords:
isoxazole, metathesis, ruthenium carbene catalyst, sulfonamide, sulfonylchlorideAbstract
A number of new chloroaryl-containing sulfonyl chlorides of isoxazole series that have been converted into the corresponding diallyl sulfonamides was synthesized by means of oxidative chlorination. The ring-closing metathesis reaction of obtained sulfonamides was conducted with the help of the ruthenium carbene catalyst. A number of new, potentially bioactive, pyroline-containing choroarylsubstituted sulfonylamide derivatives of isoxazole was synthesized.
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