Evaluation of the effect of professional irradiation on cytogenetic parameters of peripheral blood lymphocytes
DOI:
https://doi.org/10.15407/dopovidi2018.10.112Keywords:
professional exposure, blood lymphocytes, genome instability, carcinogenic risk, radiomitigatorsAbstract
The cytogenetic examination of radiologists with different work experiences in the field of ioni zing radiation has been performed. Preliminary data indicate that radiologists with over 1.5 years of experience exhibit, ~ in 70 % of cases, an increased level of chromosomal aberrations, including dicentrics and translocations (from 0.5 to 6.0 / 100 metaphases). This indicates a radiation load on the genome of the examined professionals. The radiomitiga- tors inosine and thymalin reduce the frequency of radiation-induced aberrations of chromosomes upon the ir- radiation in small doses to the values of the average population spontaneous level.
Downloads
References
Schauer, D. A. & Linton, O. W. (2009). National Council on Radiation Protection and Measurements report shows substantial medical exposure increase. Radiology, 253, No. 2, pp. 293-296. doi: https://doi.org/10.1148/radiol.2532090494
Kashcheev, V. V., Menyailo, A. N., Pryakhin, E. A., Chekin, S. Y. & Ivanov, V. K. (2015). Assessment and comparison of radiation risks of medical and professional exposures. Radiation and Risk, 24, No. 3, pp. 5-14 (in Russian).
OECD Health Data: Health care resources: OECD Health Statistics (database). doi: https://doi.org/10.1787/ct-exams-tot-table-2013-1-en
Kovalenko, Y. M. (2011). The role of digital technologies in decreasing the radiation load on the patients undergoing radiologic examinations. Ukr. Radiol. Zhurn., 19, No. 3, pp. 340-341 (in Ukrainian).
Domina, E. A. (2016). Radiogenic cancer: Epidemiology and primary prevention. Kiev: Naukova Dumka (in Russian).
Ivanov, V. K., Menyailo, A. M., Tumanov, K. A., Chekin, S. Y., Adamchik, S. A. & Mikheenko, S. G. (2016). Monitoring of professional radiation risks of the workers in the nuclear industry (ARMIR system). Radiatsiya i risk, 25, No.1, pp. 16-24 (in Russian).
Sotnik, M. V. & Azazova, T. V. (2016). Identification of markers of professional combined radiation by molecular-cytogenetic method mFISH. Radiatsiya i risk, 25, No. 3, pp. 104-113 (in Russian). doi: https://doi.org/10.21870/0131-3878-2016-25-3-104-113
Albertson, D. G., Collins, C., Cormick, F. & Gray, J. W. (2011). Chromosome aberrations in solid tumors. J. Radiat. Prot., 31, No. 1, pp. 41-48.
Radford, I. R. (2004). Chromosomal rearrangements as the basis for human tumourigenesis. Int. J. Radiat. Biol. 80, No. 8, pp. 543-557. doi: https://doi.org/10.1080/09553000412331283489
Hagmar, L., Stromberg, U. & Bonassi, S. (2004). Impact of types of lymphocytes chromosomal aberrations on human cancer risk: results from Nordic and Italian cohorts. Cancer Res., 64, No. 6, pp. 2258-2263. doi: https://doi.org/10.1158/0008-5472.CAN-03-3360
Domina, E. A. & Chekhun, V. F. (2013). Experimental validation of prevention of the development of stochastic effects of low doses of ionizing radiation based on the analysis of human lymphocytes chromosome aberrations. Exp. Oncol., 35, No. 1, pp. 65-68.
Nugis, V. Y. & Kozlova, M. G. (2017). The problem of the correlation between the frequency of chromosome aberrations in peripheral blood lymphocytes and the risk of developing diseases, including after the action of radiation. Radiats. biologiia. Radioecologiia, 57, No. 1, pp. 18-29 (in Russian).
Domina, E. A. (2016). Chromosomal abnormalities in blood lymphocytes of primary cancer patients in the post-Chernobyl period. Science Rise: Biological Science, No. 1, pp. 20-25 (in Russian).
Cytogenetic dosimetry: Applications in prepared-ness for and response to radiation emergencies (2011). Vienna: IAEA.
Peter, S., Portengen, L., Bonassi, S., Sram, R. & Vermeulen, R. (2011). Intra- and inter individual variability in lymphocyte chromosomal aberrations: implications for cancer risk assessment. Am. J. Epidem., 174, No. 4, pp. 490-493. doi: https://doi.org/10.1093/aje/kwr114
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Reports of the National Academy of Sciences of Ukraine
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
