Biochemical and cytogenetic indices of peripheral blood lymphocytes in patients with prostate cancer

Authors

  • E.A. Domina R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology
  • E.O. Stakhovskyy National Cancer Institute, Kiev
  • O.V. Safronova Clinical Нospital “Feofaniya” of State Administration of Affairs, Kiev
  • M.O. Druzhуna R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the NAS of Ukraine, Kiev
  • L.I. Makovetska R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the NAS of Ukraine, Kiev
  • O.А. Glavin R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the NAS of Ukraine, Kiev
  • Т.V. Semyglazova R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the NAS of Ukraine, Kiev

DOI:

https://doi.org/10.15407/dopovidi2018.04.102

Keywords:

blood lymphocytes, chromosome aberrations, free radical processes, prostate cancer, radiation complications

Abstract

We discuss the interindividual variability of prostate cancer patients' radiosensitivity, as well as an increase in the frequency of chromosomal exchanges in blood lymphocytes, which is associated with the inhibition of the DNA double-break repair. Patients with high activity of free radical processes require additional rehabilitation measures to prevent radiation complications.

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References

Schmitz, S., Brzozowska, K., Pinkawa, M., Eble, M. & Kriehuber, R. (2013). Chromosomal radiosensitivity analyzed by FISH in lymphocytes of prostate cancer patients and healthy donors. Radiat. Res., 180, No. 5, pp. 465-473. doi: https://doi.org/10.1667/RR3239.1

Montzka, K. & Heidenreich, A. (2010). Castration-resistant prostate cancer: definition, biology and novel thera peutic intervention strategies. Ann. Urol., 1, Iss. 1, pp. 29-34.

Domina, E.A. (2017). Individual radiosensitivity of blood lymphocytes of prostate cancer patients. Sciences of Europe, 1, No. 18, pp. 38 (in Russian).

Ke, G., Liang, L., Yang, J.M., Huang, X., Han, D., Huang, S., Zhao, Y., Zha, R., He, X. & Wu, X. (2013). MiR-181 a confers resistance of cervical cancer to radiation therapy through targeting the pro-apoptic PRK CD gene. Oncogene, 32, pp. 3019-3027. doi: https://doi.org/10.1038/onc.2012.323

Azria, D., Ozsahin, M., Kramar, A., Peters, S., Atencio, D.P., Crompton, N.E., Mornex, F., Pèlegrin, A., Dubois, J.B., Mirimanoff, R.O. & Rosenstein, B.S. (2008). Single nucleotide polymorphisms, apoptosis and the development of severe late adverse effects after radiotherapy. Clin. Cancer Res., 14, No. 19, pp. 6284-6288. doi: https://doi.org/10.1158/10780432.CCR080700

Lacombe, J., Azria, D., Mange, A. & Solassol, J. (2013). Proteomic approaches to identify biomarkers predictive of radiotherapy outcomes. Expert Rev. Proteomic., 10, No. 1, pp. 33-42. doi: https://doi.org/10.1586/epr.12.68

Shulenina, L.V., Mikhailov, V.F., Raeva, N.F., Saleyeva, D.V., Neznanova, M.V. & Zasukhina, G.D. (2017). MicroRNA in the blood of patients with prostate cancer as a possible indicator of early complications of radiation therapy. Radiatsionnaia biologiia. Radioecologiia, 57, No. 6, pp. 598-607 (in Russian).

Brzozowska, K., Pinkawa, M., Eble, M.J., Müller, W.U., Wojcik, A., Kriehuber, R. & Schmitz, S. (2012). In vivo versus in vitro individual radiosensitivity analysed in healthy donors and in prostate cancer patients with and without severe side effects after radiotherapy. Int. J. Radiat. Biol., 88, No. 5, pp. 405-413. doi: https://doi.org/10.3109/09553002.2012.666002

West, C.M., Davidson, S.E., Elyan, S.A., Valentine, H., Roberts, S.A., Swindell, R. & Hunter, R.D. (2001). Lymphocyte radiosensitivity is a significant prognostic factor for morbidity in carcinoma of the cervix. Int. J. Radiat. Oncol. Biol. Phys., 51, No. 1, pp. 10-15. doi: https://doi.org/10.1016/S0360-3016(01)01575-9

Snyder, A.R. (2004). Review of radiation-induced bystander effects. Hum. Exp. Toxicol., 23, No. 2, pp. 87-89. doi: https://doi.org/10.1191/0960327104ht423oa

Serkiz, Ya.I., Druzhyna, N.A., Khrienko, A.P., Pavlenko, I.O. & Shlumukova, I.F. (1989). Chemiluminescence of blood upon radiation exposure. Kiev: Naukova Dumka (in Russian).

L'vovskaya, E.I., Volchegorskiy, I.A., Shemyakov, S.E. & Lifshits, R.I. (1991). Spectrophotometric determi nation of lipid peroxidation terminal products. Voprosy meditsinskoy khimii, 37, No. 4, pp.92-93 (in Russian).

Liochev, S. I. & Fridovich, I. (1997). Lucigenin (bis-N-methylacridinium) as a mediator of superoxide anion production. Arch. Biochem. Biophys., 337, No. 1, pp. 115-120. doi: https://doi.org/10.1006/abbi.1997.9766

Korolyuk, M.A., Ivanova, L.I. & Mayorova, I.G. (1988). Method for determination of catalase activity. Lab. delo, No. 1, pp. 16-19 (in Russian).

Cytogenetic dosimetry: applications in preparedness for and response to radiation emergencies. (2011). Vienna: IAEA.

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Published

12.05.2024

How to Cite

Domina, E., Stakhovskyy, E., Safronova, O., Druzhуna M., Makovetska, L., Glavin, O., & Semyglazova Т. (2024). Biochemical and cytogenetic indices of peripheral blood lymphocytes in patients with prostate cancer . Reports of the National Academy of Sciences of Ukraine, (4), 102–109. https://doi.org/10.15407/dopovidi2018.04.102

Issue

No. 4 (2018): Reports of the National Academy of Sciences of Ukraine

Section

Medicine

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