The expression and the activation of protein kinase Akt/PKB in normal tissues, benign and highly differentiated malignant human thyroid tumors

Authors

  • B. B. Guda V.P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine, Kiev
  • V. M. Pushkarev V.P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine, Kiev
  • O. V. Zhuravel V.P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine, Kiev
  • V. V. Pushkarev V.P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine, Kiev
  • A.Ye. Kovalenko V.P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine, Kiev
  • Y. M. Tarachenko V.P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine, Kiev
  • M. D. Tronko V.P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine, Kiev

DOI:

https://doi.org/10.15407/dopovidi2016.07.120

Keywords:

benign tumors, malignant tumors, signaling cascade PI3K/Akt, thyroid gland

Abstract

We study the expression and the activation of the main effector protein kinase of phosphatidylinositol-3-kinase cascade (PI3K) — protein kinase Akt (v-akt murine thymoma viral oncogene homolog) in normal tissues, benign and highly differentiated (with and without metastases) human thyroid tumors. There was a difference in the Akt1 amount in tumor tissue compared with normal tissue in follicular adenomas and carcinomas. Total activity of all three isoforms Akt1/2/3 was almost completely suppressed in tumors compared to normal tissue except tissue of multinodular goiter. Thus, Akt activity is not associated with proliferative processes in the tumor tissue of the thyroid. The possible mechanisms of inhibition of signaling cascade PI3K in thyroid tumors are discussed.

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References

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Published

15.11.2024

How to Cite

Guda, B. B., Pushkarev, V. M., Zhuravel, O. V., Pushkarev, V. V., Kovalenko, A., Tarachenko, Y. M., & Tronko, M. D. (2024). The expression and the activation of protein kinase Akt/PKB in normal tissues, benign and highly differentiated malignant human thyroid tumors . Reports of the National Academy of Sciences of Ukraine, (7), 120–124. https://doi.org/10.15407/dopovidi2016.07.120

Issue

No. 7 (2016): Reports of the National Academy of Sciences of Ukraine

Section

Medicine

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