Expression and activity of extracellular signal-regulated kinase-1/2 (ERK1/2) in normal tissues and human thyroid tumors

Authors

  • B. B. Guda V.P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine, Kiev
  • V. M. Pushkarev V.P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine, Kiev
  • O. V. Zhuravel V.P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine, Kiev
  • A.Ye. Kovalenko V.P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine, Kiev
  • V. V. Pushkarev V.P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine, Kiev
  • Y. M. Tarashchenko V.P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine, Kiev
  • L. Y. Zurnadzhy V.P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine, Kiev
  • O. I. Kovzun V.P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine, Kiev
  • M. D. Tronko V.P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine, Kiev

DOI:

https://doi.org/10.15407/dopovidi2016.01.105

Keywords:

benign and malignant tumors, extracellular signal-regulated kinase-1/2, thyroid

Abstract

We studied the expression and the activation of a main effector kinase of the mitogenic cascade — extracellular signal-regulated kinase 1/2 (ERK 1/2) — in normal tissues, benign and malignant human thyroid tumors. The total content of ERK in all investigated tumors except for goiter was significantly lower in tumor tissues compared with normal tissues. ERK activity was almost completely inhibited in tumors, but not in normal tissue. Thus, ERK activity is not associated with proliferative processes in a tumor tissue of a thyroid gland. Possible mechanisms of inhibiting the activity of the mitogenic signaling cascade in thyroid tumors are discussed.

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References

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Published

29.09.2024

How to Cite

Guda, B. B., Pushkarev, V. M., Zhuravel, O. V., Kovalenko, A., Pushkarev, V. V., Tarashchenko, Y. M., Zurnadzhy, L. Y., Kovzun, O. I., & Tronko, M. D. (2024). Expression and activity of extracellular signal-regulated kinase-1/2 (ERK1/2) in normal tissues and human thyroid tumors . Reports of the National Academy of Sciences of Ukraine, (1), 105–109. https://doi.org/10.15407/dopovidi2016.01.105

Issue

No. 1 (2016): Reports of the National Academy of Sciences of Ukraine

Section

Medicine

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