Asymmetric organocatalysis — a new strategy for the construction of chiral molecules for modern engineering, technology, and medicine
Nobel Prize in Chemistry 2021
DOI:
https://doi.org/10.15407/visn2021.12.027Keywords:
asymmetric organocatalysis, chiral molecules, methods of activation of organocatalysts, achievements of Ukrainian researchersAbstract
A brief review article shows key aspects of the formation and development of asymmetric organocatalysis over the past two decades as a powerful new tool for the design of chiral organic molecules. The role of the creators of asymmetric organocatalysis strategy Benjamin List and David MacMillan, who were awarded the Nobel Prize in Chemistry in 2021, is emphasized. The fundamental advantages of the organocatalytic methodology in comparison with other methods of asymmetric synthesis have been revealed. The most typical methods of asymmetric organocatalysts activation have been analyzed and examples of new directions of their use have been given. Special attention is paid to the results of the Ukrainian scientists’ research in the field of organic organocatalysis.
