Cryobiological pedestal of the Nobel Prize in chemistry for 2017

Abstract

The article explains the core messages of the research of the Nobel Prize winners in chemistry for 2017 Jacques Dubochet, Joachim Frank, and Richard Henderson. The development of cryo-electron microscopy research is presented in historical retrospective. The importance of this discovery for the current scientific community is substantiated. The main advantages of using a high-resolution cryo-electron microscopy for determining the structure of biomolecules in solution is outlined. The review considers the practical importance of this research for medicine and biotechnology, namely in designing novel therapeutic drugs and identification of new diseases.