Mechanisms of peripheral immune tolerance, or how regulatory T-lymphocytes restrain the immune system from attacking its own body
Nobel Prize in Physiology or Medicine for 2025
DOI:
https://doi.org/10.15407/visn2025.12.003Keywords:
Nobel Prize in Physiology or Medicine 2025, Mary E. Brunkow, Fred Ramsdell, Shimon Sakaguchi, T-lymphocytes, immune system.Abstract
The 2025 Nobel Prize in Physiology or Medicine was awarded to three researchers: molecular biologist Mary E. Brunkow from the Institute for Systems Biology in Seattle (USA), scientific advisor in the biotechnology company Sonoma Biotherapeutics (USA) Fred Ramsdell, and Japanese professor of immunology at University of Osaka Shimon Sakaguchi for “discoveries concerning peripheral immune tolerance”. As noted in a press release from the Nobel Committee, this year’s laureates identified the immune system’s security guards, regulatory T cells, thus laying the foundation for a new field of research. The discoveries have also led to the “development of potential medical treatments that are now being evaluated in clinical trials. The hope is to be able to treat or cure autoimmune diseases, provide more effective cancer treatments and prevent serious complications after stem cell transplants”.
Cite this article:
Romaniuk S.I., Komisarenko S.V. Mechanisms of peripheral immune tolerance, or how regulatory T-lymphocytes restrain the immune system from attacking its own body (Nobel Prize in Physiology or Medicine for 2025). Visn. Nac. Akad. Nauk Ukr. 2025. (12): 3—19. https://doi.org/10.15407/visn2025.12.003
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