Materials and additive technologies for manufacturing polymer products for biomedical purposes
According to the report at the meeting of the Presidium of the NAS of Ukraine, June 29, 2022
DOI:
https://doi.org/10.15407/visn2022.08.071Keywords:
polylactide, silver-containing nanocomposites, 3D printing, structure, morphology, antimicrobial activity, antiviral activityAbstract
Silver-containing film materials and the technology of 3D printing of products from them with antimicrobial and antiviral effects have been developed. Film materials based on polylactide biopolymer (PLA) were created by the following methods: (1) reduction of Ag+ ions using natural extracts; (2) mechanical mixing of individually formed silver nanoparticles with the polymer matrix; (3) sputtering of nanoparticles on the surface of PLA. Filaments, which were made from the obtained film materials, were used to print polymer products on a 3D printer. The developed polymer materials demonstrate effective antimicrobial activity against S. aureus, E. coli, P. aeruginosa, C. albicans and antiviral activity against influenza A virus, herpes simplex virus 1 and adenovirus serotype 2. It was found that nanocomposites with smaller silver nanoparticles exhibited higher antimicrobial and antiviral activity. All studied silver-containing materials did not have a cytotoxic effect on MDCK, BHK-21 and Hep-2 cells, and also did not show a cytotoxic (mutagenic) effect when co-cultivated with peripheral blood lymphocytes.
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