CoAlation as a new mechanism of protection of the body from oxidative stress
Transcript of report at the meeting of the Presidium of NAS of Ukraine, November 11, 2021
DOI:
https://doi.org/10.15407/visn2022.01.030Keywords:
Coenzyme A, post-translational modifications, CoAlation, CoA synthase, antioxidant protection, tau protein CoAlation, Alzheimer’s diseaseAbstract
The report presents the results of cooperation between scientists from the Institute of Molecular Biology and Genetics of the NAS of Ukraine and the Cell Regulation Laboratory of University College London to elucidate the mechanism of biosynthesis and new functions of coenzyme A (CoA), which plays a key role in many biochemical cell reactions. For the first time in the world, the enzyme CoA synthase, which is responsible for the last two stages of CoA biosynthesis, is identified, and all enzymes involved in this process are determined. A new type of post-translational modification of proteins is established: coagulation, which has proved to be a common and universal mechanism of antioxidant protection of cell proteins and the body as a whole from oxidative stress. Emphasis is placed on the prospects of further study of the role of CoAlation in the pathogenesis of neurodegenerative diseases in order to develop modern approaches to their treatment and prevention.
