NEW LIGAND PLATFORM FOR BINUCLEAR CATALYSTS OF PHOSPHOESTER HYDROLYSIS BASED ON 8-HYDROXYQUINOLINE DERIVATIVES
DOI:
https://doi.org/10.15407/dopovidi2026.04.003Keywords:
binuclear complexes, zinc(II), 8-hydroxyquinoline, binucleating ligands, phosphoester hydrolysis, biomimetic catalysis, X-ray diffractionAbstract
A new binucleating bis(bidentate) ligand, N,N'-bis(8-hydroxyquinoline-7-carbonyl)ethylenediamine (HQen), containing two 8-hydroxyquinoline chelating sites linked by a flexible ethylenediamine spacer, was synthesized, and a binuclear zinc(II) complex [Zn2(HQen—2H)2(H2O)2] was obtained. X-ray diffraction analysis revealed that the complex is a binuclear trans-helicate in which each zinc atom occupies a distorted trigonal-bipyramidal coordination (CN = 5), formed by two N and two O donor atoms of oxyquinolinate fragments of two different ligand molecules, as well as one water molecule. The flexible amide bridges do not participate in metal coordination, forming an open cavity of the bimetallic centre. The complex exhibits catalytic activity in the hydrolytic cleavage of paraoxon-ethyl (POE) and in the transesterification of the RNA model 2-hydroxypropyl-p-nitrophenyl phosphate (HPNP); for POE hydrolysis it outperforms the known zinc-pyrazolate analogues.
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