Synthesis of hetarylsubstituted pyrazolo[3,4-c] isoquinolines under Pictet—Spengler reaction conditions
DOI:
https://doi.org/10.15407/dopovidi2018.04.081Keywords:
5-aminopyrazoles, anticancer compounds, benzothiazole, Pictet—Spengler reaction, pyrazolo[3;4-c] isoquinolines, pyridine, pyrimidineAbstract
The synthesis and reactions of 1 and 3-hetaryl-substituted 5-aminopyrazoles with aldehydes under the Pictet—Spengler reaction conditions have been studied. It has been shown that the possibility of formation and yields of pyrazolo [3,4-c] isoquinoline derivatives essentially depends on the structure and location of the heterocyclic substituent in the pyrazole core.
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