Inhibition of hemagglutinin-glycan interaction by complexes of oligoribonucleotides with D-mannitol
DOI:
https://doi.org/10.15407/dopovidi2018.01.092Keywords:
hemagglutinin, influenza virus, oligoribonucleotides-D-mannitol complexesAbstract
By the results of the indirect determination of the amount of influenza virus titer by the hemagglutination assay, it is found that oligoribonucleotides-D-mannitol (ORNs-D-M) complexes interfere with HA–glycan interactions. The infectivity of influenza virus H1N1 (A/FM/1/47) decreases after the incubation with ORNs-D-M. It is shown that ORNs-D-M possess a direct virucidal action.
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Gopinath, S. C. B. & Kumar, P. K. R. (2013). Aptamers that bind to the hemagglutinin of the recent pandemic influenza virus H1N1 and efficiently inhibit agglutination. Acta Biomaterialia, 9, pp. 8932-8941. doi: https://doi.org/10.1016/j.actbio.2013.06.016
Brooks, G. F., Butel, J. S. & Morse, S. A. (2004). Jawetz, Melnick, & Adelberg's Medical Microbiology. 22nd ed. New York: McGraw-Hill Companies.
Salzberg, S. (2008). The contents of the syringe. Nature, 454, No. 7201, pp. 160-161. doi: https://doi.org/10.1038/454160a
Davlin, S. L. (2016). Influenza activity - United States, 2015-16 season and composition of the 2016-17 influenza vaccine. Morb. Mortal. Wkly Rep., 65, No. 22, pp. 567-575. doi: https://doi.org/10.15585/mmwr.mm6522a3
Houser, K. & Subbarao, K. (2015). Influenza vaccines: Challenges and solutions. Cell Host Microbe, 17, No. 3, pp. 295-300. doi: https://doi.org/10.1016/j.chom.2015.02.012
Hensley, S. E. (2014). Challenges of selecting seasonal influenza vaccine strains for humans with diverse preexposure histories. Curr. Opin. Virol., 8, pp. 85-89. doi: https://doi.org/10.1016/j.coviro.2014.07.007
Beigel, J. & Bray, M. (2008). Current and future antiviral therapy of severe seasonal and avian influenza. Antiviral Res., 78, No. 1, pp. 91-102. doi: https://doi.org/10.1016/j.antiviral.2008.01.003
Pat. 8420617 US. IPC C07H21/04, A61K31/70, C12Q1/68, C07H21/02, Multiantivirus compound, composition and method for treatment of virus diseases, Tkachuk, Z. Publ. 16.04.2013.
Tkachuk, Z. Y., Zarubayev, V. V. & Semernikova, L. I. (2011). The antivirus action of Nuclex on the viruses of influenza, parainfluenza and bird flu in vitro. Ukr. med. almanakh., 14, No. 6, pp. 209-212 (in Ukrainian).
Tkachuk, Z. Y., Rybalko, S. L., Zharkova, L. D., Starostyla, D. B. & Semernikova, L. I. (2010). Antiinfluenzal activity of drug Nuclex. Dopov. Nac. acad. nauk Ukr., No. 9, pp. 191-196 (in Ukrainian).
Reed, L. J. & Muench, H. (1938). A simple method of estimating fifty percent endpoints. Amer. J. Hygiene, 27, pp. 493-497.
Killian, M. L. (2008). Hemagglutination assay for the avian influenza virus. Methods Mol. Biol., 436, pp. 47-52. doi: https://doi.org/10.1007/978-1-59745-279-3_7
Wongphatcharachai, M., Wang, P., Enomoto, S., Webby, R. J. & Gramer, M. R. (2013). Neutralizing DNA aptamers against swine influenza H3N2 viruses. J. Clin. Microbiol., 51, pp. 46-54. doi: https://doi.org/10.1128/JCM.02118-12
Skorobogatov, O. Yu., Lozhko, D. N., Zhukov, Yu. I., Kozlov, O. V. & Tkachuk, Z. Yu. (2014). Study of dephosphorylated 2'-5'-linked oligoadenylates impact on apo-S100A1 protein conformation by heteronuclear NMR and circular dichroism. Biopolymers and Cell, 30, No. 4, pp. 279-285. doi: https://doi.org/10.7124/bc.0008A1
Takizawa, T., Matsukawa, S., Higuchi, Y., Nakamura, S., Nakanishi, Y. & Fukuda, R. (1993). Induction of programmed cell death (apoptosis) by influenza virus infection in tissue culture cells. J. Gen. Virol., 74, pp. 2347-2355. doi: https://doi.org/10.1099/0022-1317-74-11-2347
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