COMPARATIVE EFFECTIVENESS OF THE ANTI-AGING EFFECT OF ORTHOVANADATE NANOPARTICLES, METFORMIN, AND CALORIE-RESTRICTED DIET IN EXPERIMENTAL ACCELERATED AGING OF RATS
DOI:
https://doi.org/10.15407/dopovidi2023.06.049Keywords:
GdVO4/Eu3+ nanoparticles, calorie-restricted diet, metformin, accelerated aging, rats, survival, prooxidantantioxidant balanceAbstract
The effects of orthovanadate nanoparticles (GdVO4/Eu3+ NPs (8 × 25 nm)), a calorie-restricted diet, and the calorie restriction-mimetic metformin on survival and the prooxidant-antioxidant balance in the liver and blood of male Wistar rats, in which accelerated aging was modeled under overfeeding in early postnatal ontogeny, were investigated. The survival rate of rats with accelerated aging was found to be lower than that of control animals. Additionally, the rate of formation of superoxide radicals and the content of lipid hydroperoxides were higher in the mitochondria and microsomes of the liver and blood serum of young overfeeding rats, while the activity of glutathione peroxidase and the content of GSH were significantly lower than in control animals. Long-term administration of nanoparticles, a calorie-restricted diet, or metformin to rats with accelerated aging normalized the prooxidant-antioxidant balance in the studied tissues and significantly increased the survival rate of these experimental animals. Notably, the increase in survival was more pronounced due to the calorie-restricted diet and nanoparticle application. Considering the literature data on the inadmissibility of long-term use of a low-calorie diet in humans, as well as the ambiguity of the literature data on the geroprotective effect of metformin, the results obtained lead to the conclusion that GdVO4/Eu3+ nanoparticles are currently considered more promising for developing means to slow down accelerated aging in an organism.
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