Cholesterol and its esters in the bile of rats in tetracyclineinduced hepatosis and under the using of milk phospholipids
DOI:
https://doi.org/10.15407/dopovidi2020.12.093Keywords:
bile, cholesterol, cholesterol’s esters, milk phospholipids, rats, steatosis, tetracyclineAbstract
The increase of disorders of the cholesterol metabolism and the bile formation determines the need of the search for possible substances correcting the cholesterol metabolism in the liver. It is found that, in laboratory rats with an experimental drug form of steatosis, the excretion of cholesterol and, especially, cholesterol esters to the bile ducts is inhibited, and their ratio in bile is significantly impaired. The use of bioadditive “FLP-MD” made on milk phospholipids has a corrective effect on the concentration of cholesterol and its esters in bile of rats with tetracycline-induced steatosis. This allows us to recommend bioadditive “FLP-MD” made on milk phospholipids to improve the cholesterol metabolism in patients with clinical cases of drug-induced liver damage.
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