GLASSY CARBON-IRON POWDER COMPOSITE WITH CHEMICAL RESISTANCE IN BIOLOGICAL FLUIDS FOR MEDICAL PURPOSES

Abstract

The technology for obtaining the composite powder glassy carbon-iron material (KPMSZ) by the modified method of chemically pure sucrose thermal destruction in the special technological conditions has been developed in the work. The experimental samples with a metal component content ranging from 7.7 to14.5 wt. % in the initial product were obtained. Using the methods of X-ray structural analysis and coherent scattering regions calculations has been established that the metal phase in the investigated composites consists of a mixed-соmpleted oxide FeO·Fe₂O₃ with a particle size of 10-40 nm. It has been proven that the developed powders retain their phase composition after interaction with human blood plasma, and their specific surface area remains virtually unchanged. This indicates sufficient stability of particle sizes after interaction of the powders with the studied model biological media. The study of inorganic and biological media filtrates after their interaction with KPMSZ powders showed that iron was released from the composite into the blood plasma approximately 4.6 times more intensively than into water and physiological solution. Its level was practically the same for samples with 7.7 and 14.5 wt % and may be associated with the presence of iron-binding proteins in blood plasma. According to literature data, iron in such proteins exists in a bound form that is easily absorbed state by the body. Using electron microscopy method, it was established that after interaction with model biological environments, the resulting composite powders of glass carbon and iron did not form morphological particles that could damage body tissues and cells in the body. Based on the experimental data obt ained, it was proven that the developed composite powdered glass-carbon-iron material, which possesses phase, morphological, and sufficient chemical stability in biological environments, is a promising material for further developments in the field of medicine.