Bioactive polyurethane ureas with physically immobilized folate-ferrocene conjugate
DOI:
https://doi.org/10.15407/dopovidi2014.10.131Keywords:
folate-ferrocene conjugate, polyurethaneAbstract
New polyurethane ureas based on polyoxypropylene glycol and 2,4-,2,6-toluene diisocyanate, using diamines (1,6-hexamethylenediamine or 4,4′-diaminodiphenylmethane) as chain extenders and physically immobilized folate-ferrocene conjugate, are synthesized. IR-spectroscopic, physical, and mechanical investigations are carried out. Pharmacokinetic studies of the prolonged form of folateferrocene conjugate, contained in polyurethane ureas, testify to the bioactivity of the obtained polymeric materials.
Downloads
References
Mazur L. M., Rozhnova R. A., Drozdova V. I., Galatenko N. A. Polimer. zhurn., 2007, 29, No 1: 58–66 (in Ukrainian).
Zhernova L. M., Lugovska G. G., Pochynok O. V., Galatenko N. A. Kompozyts. polimer. materialy, 2001, No 10: 139–143 (in Ukrainian).
Andryushina O. S., Rozhnova R. A., Galatenko N. A., Narazhaiko L. F. Nauk. zap. NaUkMA. Ser. Khim. nauky i tekhnologii, 2010, 105: 47–50 (in Ukrainian).
Galatenko N. A., Rozhnova R. A., Andryushina E. S. et al. Plast. ta rekonstrukt. khirurgiia, 2013, No 1: 45–54 (in Russian).
Demchenko I. B., Galatenko N. A., Makeeva L. V. et al. Dopov. Nac. akad. nauk Ukr., 2013, No 3: 143–148 (in Russian).
Makeeva L. V., Gladir I. I., Rozhnova R. A., Demchenko I. B. Dopov. Nac. akad. nauk Ukr., 2013, No 1: 132–137 (in Ukrainian).
Organikum. Workshop on organic chemistry. Vols. 2, Vol. 1. (Bekker G., Berger V., Domshke G., Fangkhenel E., Faust Yu., Fisher M., Gents F., Govald K., Glukh R., Maier R., Myuller K., Pavel D., Schmidt G., Sholberg K., Shvetlik K., Zeiler E., Tseppnefeld G.), Moscow: Mir, 1979 (in Russian).
GOST 25.601–80. Methods of mechanical testing of polymeric composite materials. Test for tensile properties on plane specimens at normal, elevated and low temperatures, Moscow: Izd-vo standartov, 1980 (in Russian).
Komarov F. I., Korovkin B. F., Menshikov V. V. Biochemical studies in the clinic, 1976 (in Russian).
Kokunin V. A. Ukr. biokhim. zhurn., 1975, 47, No 6: 776–790 (in Russian).
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Reports of the National Academy of Sciences of Ukraine
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
