Sensitivity of Lewis Lung Carcinoma (LLC) and LLC/R9 cells to cytotoxic action exerted by murine natural killer cells and macrophages of C57BL/6 mice in vitro
DOI:
https://doi.org/10.15407/dopovidi2014.06.167Keywords:
killer cells, Lewis lung carcinoma, macrophages of miceAbstract
The comparative investigation of the sensitivity of primary LLC and drug resistant LLC/R9 cells to natural killer cells and macrophages of C57BL/6 intact mice is performed in vitro. It is shown that the forming of a resistance to cisplatin by LLC cells is accompanied by an increase of their sensitivity to the cytotoxic action of natural killer cells and a decrease of the susceptibility to the cytolytic activity of macrophages. High LLC/R9 cell sensitivity to the cytotoxic action of natural killer cells possibly was caused by a diminished expression of MHC class I molecules. Decreased sensitivity of resistant cells to the cytolysis by nonsensitized macrophages was associated with a high ability to undergo autophagy.
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