Properties of pyrrol derivatives as potential anticancer compounds of a new generation
DOI:
https://doi.org/10.15407/dopovidi2014.05.138Keywords:
anticancer compounds, pyrrolAbstract
The effects of pyrrol derivatives 5-amyno-4-(1,3-benzothyazol-2-yl)-1-(3-methoxyphenyl)-1,2-dihydro-3H-pyrrol-3-one and 1-(4-Cl-benzyl)-3-Cl-4-(CF3-phenylamino)-1H-pyrrol-2,5-dione on rat intestine and liver under 1,2-dimethylhydrazine-induced colon cancer are investigated. Low toxicity, antitumor activity, antioxidant and membranotropic properties of these compounds are observed.
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References
Bray F., Jemal A., Grey N. et al. Lancet Oncol., 2012, 13: 790–801. https://doi.org/10.1016/S1470-2045(12)70211-5
Teletaeva G. M. Praktich. onkologiia, 2009, 10, No. 3: 158–167 (in Russian).
Singer C. F. Wien. Med. Wochenschr., 2010, 160, No. 19–20: 501–505. https://doi.org/10.1007/s10354-010-0839-5
Tryakin A. A. Praktich. onkologiia, 2010, 11: 143–150 (in Russian).
Pat. 22204 UA, IPC A61K31/40. Compound of 1,4-disubstituted 5-amino-1,2-dihydropyrol-3-on, having anticarcinogenic activity. Dubinina G. G., Volovenko Yu. M. Publ. 25.04.2007 (in Ukrainian).
Garmanchuk L. V., Senchylo N. V., Nikulina V. V. et al. Fizyka zhyvogo, 2011, 19, No. 2: 51–53 (in Ukrainian).
Perse M., Cerar A. Radiol. Oncol., 2005, 39, No. 1: 61–70.
Pozharisski K. N. IARC Sci. Publ., 1990, 99: 159–198.
Goralskii L. P., Khomich V. T., Kononskii O. I. Fundamentals histological technique i morfofunktsionalni methods of research in norm and in pathology. Manuals. Zhytomyr: Polissia, 2005 (in Ukrainian).
Yablonska S. V., Filinska O. M., Ostrovska G. V., Rybalchenko V. K. Ukr. biokhim. zhurn., 2009, 81, No. 5: 83–92 (in Ukrainian).
Kaliman P. A., Okhrimenko S. M. Ukr. biokhim. zhurn., 2005, 77, No. 2: 154–158 (in Russian).
Burlaka A. P., Sydoryk E. P. The radical oxygen species and nitric oxide with cancer. Kyiv: Nauk. dumka, 2006 (in Ukrainian).
Schreiner R., Fouzon R., Curtin D. Identification of organic compounds. Moscow: Nauka, 1983 (in Russian).
Omelchenko A. M., Bovykin B. A., Sytnik T. V. Mol. genetika i biofizika, 1990, 15: 17 (in Russian).
Ostrovska G. V. Primary mechanisms of membrane modulating action of bioregulators of natural and synthetic origin. (Extended abstract of candidate thesis), Kyiv, Ukraine, 2005 (in Ukrainian).
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