Regulatory effect of vitamin D3 on proinflammatory processes in liver of diabetic mice

Authors

  • D. O. Labudzynskyi Palladin Institute of Biochemistry of the NAS of Ukraine, Kiev
  • K. I. Kubaichuk Palladin Institute of Biochemistry of the NAS of Ukraine, Kiev
  • I. O. Shymanskyi Palladin Institute of Biochemistry of the NAS of Ukraine, Kiev
  • M. M. Veliky Palladin Institute of Biochemistry of the NAS of Ukraine, Kiev

DOI:

https://doi.org/10.15407/dopovidi2016.06.127

Keywords:

cytokines, diabetes mellitus, vitamin D3

Abstract

It is shown that the induction of pluripotent proinflammatory interleukin 6 (IL-6) in liver in diabetes is accompanied by increased expression of osteopontin (OPN) — molecular regulator of the synthesis of proinflammatory cytokines. Changes in the OPN and IL-6 expression correlate with a significant deficiency of vitamin D3 in organism. Normalization of the vitamin D3 level leads to a substantial reduction of the expression level of both OPN and IL-6 mRNA, showing the cytoprotective effect of cholecalciferol in diabetes-induced liver disorders.

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Published

03.11.2024

How to Cite

Labudzynskyi, D. O., Kubaichuk, K. I., Shymanskyi, I. O., & Veliky, M. M. (2024). Regulatory effect of vitamin D3 on proinflammatory processes in liver of diabetic mice . Reports of the National Academy of Sciences of Ukraine, (6), 127–132. https://doi.org/10.15407/dopovidi2016.06.127

Issue

No. 6 (2016): Reports of the National Academy of Sciences of Ukraine

Section

Biochemistry

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