An interaction of the copper nanoparticles-ceftriaxone conjugate with protein, lipid, and carbohydrate components of bacterial cell envelope

Authors

  • P. V. Simonov Bogomolets National Medical University, Kiev
  • D. O. Kovalyova Taras Shevchenko National University of Kiev
  • Т. О. Busko Taras Shevchenko National University of Kiev
  • О. P. Dmytrenko Taras Shevchenko National University of Kiev
  • М. P. Kulysh Taras Shevchenko National University of Kiev
  • М. А. Zabolotniy Taras Shevchenko National University of Kiev
  • М. О. Kuzmenko Taras Shevchenko National University of Kiev
  • I. S. Chekman Bogomolets National Medical University, Kiev

DOI:

https://doi.org/10.15407/dopovidi2016.05.125

Keywords:

ceftriaxone, copper nanoparticles, conjugate, bacterial cell envelope component

Abstract

A possibility of an interaction of the copper nanoparticles-ceftriaxone conjugate with protein, lipid, and hydrocarbon components of a cell envelope of gram-positive and gram-negative bacteria is studi- ed by the means of quantum-chemical calculations and the optical spectroscopy. It is found out that the positions and half-widths of dipole-allowed optical absorption bands in solutions of the copper nanoparticles-ceftriaxone conjugate with the aforementioned substances are changed. It is shown that the ceftriaxone electronic state is changed because of the intensification of its interaction with components of a cell envelope due to the presence of metal nanoparticles.

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Published

27.10.2024

How to Cite

Simonov, P. V., Kovalyova, D. O., Busko Т. О., Dmytrenko О. P., Kulysh М. P., Zabolotniy М. А., Kuzmenko М. О., & Chekman, I. S. (2024). An interaction of the copper nanoparticles-ceftriaxone conjugate with protein, lipid, and carbohydrate components of bacterial cell envelope. Reports of the National Academy of Sciences of Ukraine, (5), 125–131. https://doi.org/10.15407/dopovidi2016.05.125

Issue

No. 5 (2016): Reports of the National Academy of Sciences of Ukraine

Section

Medicine

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