Полювання вчених на коронавірус SARS-COV-2, що викликає COVID-19: наукові стратегії подолання пандемії

Автор(и)

  • Сергій Васильович Комісаренко академік НАН України і НАМН України, академік-секретар Відділення біохімії, фізіології і молекулярної біології НАН України, директор Інституту біохімії ім. О.В. Палладіна НАН України, голова робочої групи НАН України з проблем (наслідків) поширення коронавірусу SARS-CoV-2 в Україні https://orcid.org/0000-0002-3244-3194

DOI:

https://doi.org/10.15407/visn2020.08.029

Ключові слова:

COVID-19 pandemic, SARS-CoV-2 coronavirus, ways of infection, COVID-19 diagnosis, anti-viral immunity, vaccines, models of the epidemic process

Анотація

У статті наведено широкий і ґрунтовний аналіз поточної ситуації щодо пандемії COVID-19. Розглянуто питання походження та будови вірусу SARS-CoV-2, шляхів інфікування, особливостей перебігу захворювання, діагностики COVID-19, застосування фармацевтичних препаратів для лікування хвороби, формування імунітету проти SARS-CoV-2, створення вакцин та ефективності протиепідемічних карантинних заходів. Обговорено використання математичних моделей епідемічного процесу та перспектив виходу з карантину.

Посилання

Reimann H.A. Landmark article Dec 24, 1938: An acute infection of the respiratory tract with atypical pneumonia. A disease entity probably caused by a filtrable virus. JAMA. 1984. 251(7): 936–944. DOI: https://doi.org/10.1001/jama.251.7.936

Severe acute respiratory syndrome. https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome

Middle East respiratory syndrome. https://en.wikipedia.org/wiki/Middle_East_respiratory_syndrome

COVID-19 Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU). https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6

In Ukraine — the first case of coronavirus. Ukrayinska pravda. March 3, 2020 (in Ukrainian). https://www.pravda.com.ua/news/2020/03/3/7242332/

Wee S.-L., McNeil D.G.Jr. China Identifies New Virus Causing Pneumonialike Illness. https://www.nytimes.com/2020/01/08/health/china-pneumonia-outbreak-virus.html

Lu R., Zhao X., Li J. et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020. 395(10224): 565–574. DOI: https://doi.org/10.1016/s0140-6736(20)30251-8

Beaudette F.R., Hudson C.B. Cultivation of the virus of infectious bronchitis. J. Am. Vet. Med. Assoc. 1937. 90: 51–58.

Tyrrell D.A., Bynoe M.l. Cultivation of a novel type of common-cold virus in organ cultures. Br. Med. J. 1965. 1(5448): 1467–1470. DOI: https://doi.org/10.1136/bmj.1.5448.1467

Woo P.C., Lau S.K., Huang Y., Yuen K.Y. Coronavirus diversity, phylogeny and interspecies jumping. Exp. Biol. Med. (Maywood). 2009. 234(10): 1117–1127. DOI: https://doi.org/10.3181/0903-mr-94

Derek Wong’s Virology. http://virology-online.com/viruses/CORZA4.htm

Phylogeny of SARS-like betacoronaviruses including novel coronavirus SARS-CoV-2. https://nextstrain.org/groups/blab/sars-like-cov

Davidson H. First Covid-19 case happened in November, China government records show — report. https://www.theguardian.com/world/2020/mar/13/first-covid-19-case-happened-in-november-china-government-records-show-report

Huang C., Wang Y., Li X. et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020. 395(10223): 497–506. DOI: https://doi.org/10.1016/S0140-6736(20)30183-5

Osborne H. Coronavirus Outbreak May Have Started As Early As September, Scientists Say. https://www.newsweek.com/coronavirus-outbreak-september-not-wuhan-1498566

Zhou P., Yang X.L., Wang X.G. et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020. 579(7798): 270–273. DOI: https://doi.org/10.1038/s41586-020-2012-7

Readfearn G. How did coronavirus start and where did it come from? Was it really Wuhan’s animal market? https://www.theguardian.com/world/2020/apr/28/how-did-the-coronavirus-start-where-did-it-come-from-how-did-it-spread-humans-was-it-really-bats-pangolins-wuhan-animal-market

Liu P., Jiang J.Z., Wan X.F., Hua Y., Li L., Zhou J., Wang X., Hou F., Chen J., Zou J., Chen J. Are pangolins the intermediate host of the 2019 novel coronavirus (SARS-CoV-2)? PLoS Pathog. 2020. 16(5): e1008421. DOI: https://doi.org/10.1371/journal.ppat.1008421

Andersen K.G., Rambaut A., Lipkin W.I., Holmes E.C., Garry R.F. The proximal origin of SARS-CoV-2. Nat. Med. 2020. 26(4): 450–452. DOI: https://doi.org/10.1038/s41591-020-0820-9

Shinkman P.D. U.S. Spy Agencies Weigh In on Coronavirus Rumors. https://www.usnews.com/news/national-news/articles/2020-04-30/coronavirus-not-man-made-director-of-national-intelligence-says

Sanger D.E. Pompeo Ties Coronavirus to China Lab, Despite Spy Agencies’ Uncertainty. https://www.nytimes.com/2020/05/03/us/politics/coronavirus-pompeo-wuhan-china-lab.html

Pennisi E. How bats have outsmarted viruses — including coronaviruses — for 65 million years. Science. Jul. 22, 2020. DOI: https://doi.org/10.1126/science.abd9595

Scudellari M. The sprint to solve coronavirus protein structures — and disarm them with drugs. Nature News. 15 May 2020. DOI: https://doi.org/10.1038/d41586-020-01444-z

Zhang L., Lin D., Sun X. et al. Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors. Science. 2020. 368(6489): 409–412. DOI: https://doi.org/10.1126/science.abb3405

Wu F., Zhao S., Yu B., Chen Y.M., Wang W., Song Z.G., Hu Y., Tao Z.W., Tian J.H., Pei Y.Y., Yuan M.L., Zhang Y.L., Dai F.H., Liu Y., Wang Q.M., Zheng J.J., Xu L., Holmes E.C., Zhang Y.Z. A new coronavirus associated with human respiratory disease in China. Nature. 2020. 579(7798): 265–269. DOI: https://doi.org/10.1038/s41586-020-2008-3

Schmidt A., Wolff M.H., Weber O. Coronaviruses with special emphasis on first insights concerning SARS. Springer, 2005. 232 p. DOI: https://doi.org/10.1007/b137625

Wrapp D., Wang N., Corbett K.S., Goldsmith J.A., Hsieh C.-L., Abiona O., Graham B.S., McLellan J.S. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science. 2020. 367(6483): 1260–1263. DOI: https://doi.org/10.1126/science.abb2507

Zhang X., Li Sh., Niu Sh. ACE2 and COVID-19 and the Resulting ARDS. Postgrad. Med. J. 2020. 96(1137): 403–407. https://doi.org/10.1136/postgradmedj-2020-137935

Watanabe Ya., Allen J.D., Wrapp D., McLellan J.S., Crispin M. Site-specific glycan analysis of the SARS-CoV-2 spike. Science. 2020. 369(6501): 330–333. DOI: https://doi.org/10.1126/science.abb9983

Hoffman M. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020. DOI: https://doi.org/10.1016/j.cell.2020.02.052

Sakai K., Ami Y., Tahara M. et al. The Host Protease TMPRSS2 Plays a Major Role in in Vivo Replication of Emerging H7N9 and Seasonal Influenza. Viruses J. Virol. 2014. 88(10): 5608–5616. DOI: https://doi.org/10.1128/JVI.03677-13

Vankadari N., Wilce J.A. Emerging WuHan (COVID-19) Coronavirus: Glycan Shield and Structure Prediction of Spike Glycoprotein and Its Interaction With Human CD26. Emerg. Microbes Infect. 2020. 9(1): 601–604. DOI: https://doi.org/10.1080/22221751.2020.1739565

Wang K., Chen W., Zhou Y.-S. et al. SARS-CoV-2 invades host cells via a novel route: CD147-spike protein. bioRxiv. DOI: https://doi.org/10.1101/2020.03.14.988345

Castelvetri L.C., Ojha R., Pedro L.D. et al. Neuropilin-1 facilitates SARS-CoV-2 cell entry and provides a possible pathway into the central nervous system. BioRxiv preprint. DOI: https://doi.org/10.1101/2020.06.07.137802

Jia Y., Shen G., Zhang Y., Huang K.-S., Ho H.-Y., Hor W.-S., Yang C.-H., Li C., Wang W.-L. Analysis of the mutation dynamics of SARS-CoV-2 reveals the spread history and emergence of RBD mutant with lower ACE2 binding affinity. BioRxiv. 2020. DOI: https://doi.org/10.1101/2020.04.09.034942

Zhang L., Jackson C.B., Mou H., Ojha A., Rangarajan E.S., Izard T., Farzan M., Choe H. The D614G mutation in the SARS-CoV-2 spike protein reduces S1 shedding and increases infectivity. BioRxiv. June 12, 2020. DOI: https://doi.org/10.1101/2020.06.12.148726

Thao T.T.N., Labroussaa F., Ebert N. et al. Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform. Nature. 2020. DOI: https://doi.org/10.1038/s41586-020-2294-9

Sun J., Zhuang Zh., Zheng J. et al. Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment. Cell. 2020. 182: 1–10. DOI: https://doi.org/10.1016/j.cell.2020.06.010

Gaglia M., Lakdawala S. What we do and do not know about COVID-19’s infectious dose and viral load. https://theconversation.com/what-we-do-and-do-not-know-about-covid-19s-infectious-dose-and-viral-load-135991

Wang W., Xu Y., Gao R., Lu R., Han K., Wu G., Tan W. Detection of SARS-CoV-2 in Different Types of Clinical Specimens. JAMA. 2020. 323(18): 1843–1844. DOI: https://doi.org/10.1001/jama.2020.3786

Meyerowitz E.A., Richterman A.G., Quick M.P.H. A Summary of the COVID-19 Literature So Far. Medscape. May 18, 2020. https://www.medscape.com/viewarticle/930588

To K.K., Tsang O.T., Chik-Yan Y.C. et al. Consistent detection of 2019 novel coronavirus in saliva. Clinical Infectious Diseases. 2020. DOI: https://doi.org/10.1093/cid/ciaa149

Sex and Coronavirus Disease 2019 (COVID-19). https://www1.nyc.gov/assets/doh/downloads/pdf/imm/covid-sex-guidance.pdf

Mandavilli A. Infected but Feeling Fine: The Unwitting Coronavirus Spreaders. The New York Times. July 9, 2020. https://www.nytimes.com/2020/03/31/health/coronavirus-asymptomatic-transmission.html

Petri W. Infected with the coronavirus but not showing symptoms? A physician answers 5 questions about asymptomatic COVID-19. The Conversation. https://theconversation.com/infected-with-the-coronavirus-but-not-showing-symptoms-a-physician-answers-5-questions-about-asymptomatic-covid-19-137029

van Doremalen N., Bushmaker T., Morris D.H., Holbrook M.G., Gamble A., Williamson B.N., Tamin A., Harcourt J.L., Thornburg N.J., Gerber S.I., Lloyd-Smith J.O., de Wit E., Munster V.J. Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1. N. Engl. J. Med. 2020. 382(16): 1564–1567. DOI: https://doi.org/10.1056/NEJMc2004973

Sungnak W., Huang N., Becavin C., Berg M., Queen R., Litvinukova M., Talavera-Lopez C., Maatz H., Reichart D., Sampaziotis F., Worlock K.B., Yoshida M., Barnes J.L., Lung H.C.A. SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nat. Med. 2020. 26: 681–687. DOI: https://doi.org/10.1038/s41591-020-0868-6

All Your Coronavirus Questions, Answered. Time. May 8, 2020. https://time.com/5820118/coronavirus-questions-answered/

Lewis D. Is the coronavirus airborne? Experts can’t agree. Nature News. April 2, 2020. https://www.nature.com/articles/d41586-020-00974-w

Harrison L. Speech May Spread More COVID-19 Than Feces. Medscape. 19 May 2020. https://www.medscape.com/viewarticle/930799

Coronavirus: WHO rethinking how Covid-19 spreads in air. BBC News. 8 July 2020. https://www.bbc.com/news/world-53329946

Rapid Expert Consultation on SARS-CoV-2 Survival in Relation to Temperature and Humidity and Potential for Seasonality for the COVID-19 Pandemic (April 7, 2020). https://www.nap.edu/read/25771/chapter/1

Recommendation Regarding the Use of Cloth Face Coverings, Especially in Areas of Significant Community-Based Transmission. https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/cloth-face-cover.html

Advice on the use of masks in the context of COVID-19. https://www.who.int/publications-detail/advice-on-the-use-of-masks-in-the-community-during-home-care-and-in-healthcare-settings-in-the-context-of-the-novel-coronavirus-(2019-ncov)-outbreak

Estimating the number of infections and the impact of non-pharmaceutical interventions on COVID-19 in 11 European countries. https://www.imperial.ac.uk/media/imperial-college/medicine/mrc-gida/2020-03-30-COVID19-Report-13.pdf

Mizutani T. Signal transduction in SARS-CoV-infected cells. Ann. NY Acad. Sci. 2007. 1102: 86–95. DOI: https://doi.org/10.1196/annals.1408.006

Zimmer C. DNA Inherited From Neanderthals May Increase Risk of Covid-19. The New York Times. July 4, 2020. https://www.nytimes.com/2020/07/04/health/coronavirus-neanderthals.html

Osterweil N. Case Fatality Rate for COVID-19 Near 1.4%, Increases With Age. https://www.medscape.com/viewarticle/927870

Rabin R.C. In Italy, Coronavirus Takes a Higher Toll on Men. https://www.nytimes.com/2020/03/20/health/coronavirus-italy-men-risk.html

Wenham C., Smith J., Morgan R. COVID-19: the gendered impacts of the outbreak. Lancet. 2020. 395(10227): 846–848. DOI: https://doi.org/10.1016/S0140-6736(20)30526-2

Coronavirus in NY: Cases, maps, charts and resources. https://www.syracuse.com/coronavirus-ny/

Wadman M. Sex hormones signal why virus hits men harder. Science. 2020: 368(6495): 1038–1039. DOI: https://doi.org/10.1126/science.368.6495.1038

Zaiets K., Padilla R. Coronavirus, diabetes, obesity and other underlying conditions: Which patients are most at risk? https://www.usatoday.com/in-depth/news/2020/04/15/coronavirus-risk-90-patients-had-underlying-conditions/2962721001/

Mallapaty S. Mounting clues suggest the coronavirus might trigger diabetes. https://www.nature.com/articles/d41586-020-01891-8

Tan T., Khoo B., Mills E.G. et al. Association Between High Serum Total Cortisol Concentrations and Mortality From COVID-19. Lancet Diabetes Endocrinol. 2020. 8(8): 659-660. DOI: https://doi.org/10.1016/S2213-8587(20)30216-3

Balfour H. Blood test could identify those most at risk from COVID-19. Drug Target Review. 22 May 2020. https://www.drugtargetreview.com/news/61778/blood-test-could-identify-those-most-at-risk-from-covid-19/

Yan L., Zhang H.-T., Goncalves J. et al. An interpretable mortality prediction model for COVID-19 patients. Nat. Mach. Intell. 2020. 2: 283–288. DOI: https://doi.org/10.1038/s42256-020-0180-7

Yong Sh.J. Vitamin D as an Independent Risk Factor for COVID-19 Death. https://medium.com/microbial-instincts/lack-of-vitamin-d-as-an-independent-risk-factor-for-covid-19-death-82365d0520fa

Fang L., Karakiulakis G., Roth M. Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? The Lancet. 2020. 8(4): E21. DOI: https://doi.org/10.1016/s2213-2600(20)30116-8

Sama I.E., Ravera A., Santema B.T. et al. Circulating Plasma Concentrations of Angiotensin-Converting Enzyme 2 in Men and Women With Heart Failure and Effects of Renin-Angiotensin-Aldosterone Inhibitors. Eur. Heart J. 2020. 41(19): 1810–1817. DOI: https://doi.org/10.1093/eurheartj/ehaa373

Murray S. New Evidence Concerning Safety of ACE Inhibitors, ARBs in COVID-19. https://www.pharmacytimes.com/news/new-evidence-concerning-safety-of-ace-inhibitors-arbs-in-covid-19

de Simone G. Position Statement of the ESC Council on Hypertension on ACE-Inhibitors and Angiotensin Receptor Blockers. Council on Hypertension of the European Society of Cardiology. 13 Mar 2020. https://www.escardio.org/Councils/Council-on-Hypertension-(CHT)/News/position-statement-of-the-esc-council-on-hypertension-on-ace-inhibitors-and-ang

Radzikowska U., Ding M., Tan G. et al. Distribution of ACE2, CD147, CD26 and Other SARS-CoV-2 Associated Molecules in Tissues and Immune Cells in Health and in Asthma, COPD, Obesity, Hypertension, and COVID-19 Risk Factors. Allergy. 2020. DOI: https://doi.org/10.1111/all.14429

Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19). https://www.who.int/docs/default-source/coronaviruse/who-china-joint-mission-on-covid-19-final-report.pdf

Liu R., Wang Y., Li J., Han H., Xia Z., Liu F., Wu K., Yang L., Liu X., Zhu C. Decreased T cell populations contribute to the increased severity of COVID-19. Clin. Chim. Acta. 2020. DOI: https://doi.org/10.1016/j.cca.2020.05.019

Ying T., Li W., Dimitrov D.S. Discovery of T-Cell Infection and Apoptosis by Middle East Respiratory Syndrome Coronavirus. J. Infect. Dis. 2016. 213(6): 877–879. DOI: https://doi.org/10.1093/infdis/jiv381

Shoenfeld Y. Corona (COVID-19) time musings: Our involvement in COVID-19 pathogenesis, diagnosis, treatment and vaccine planning. Autoimmun. Rev. 2020. 19(6): 102538. DOI: https://doi.org/10.1016/j.autrev.2020.102538

Cascella M., Rajnik M., Cuomo A., Dulebohn S.C., Di Napoli R. Features, Evaluation and Treatment Coronavirus (COVID-19). (Treasure Island (FL): Stat Pearls Publishing, 2020).

Long B., Brady W.J., Koyfman A., Gottlieb M. Cardiovascular complications in COVID-19. The American Journal of Emergency Medicine. 2020. DOI: https://doi.org/10.1016/j.ajem.2020.04.048

Xu L., Liu J., Lu M., Yang D., Zheng X. Liver injury during highly pathogenic human coronavirus infections. Liver International. 2020. 40(5): 998–1004. DOI: https://doi.org/10.1111/liv.14435

Riphagen S., Gomez X., Gonzalez-Martinez C., Wilkinson N., Theocharis P. Hyperinflammatory shock in children during COVID-19 pandemic. The Lancet. 2020. DOI: https://doi.org/10.1016/s0140-6736(20)31094-1

Kwon D. From Headaches to ‘COVID Toes,’ Coronavirus Symptoms Are a Bizarre Mix. Blood clots and inflammation may underlie many of these complications. https://www.scientificamerican.com/article/from-headaches-to-covid-toes-coronavirus-symptoms-are-a-bizarre-mix1/

Carod-Artal F.J. Neurological complications of coronavirus and COVID-19. Revista de Neurologia. 2020. 70(9): 311–322. DOI: https://doi.org/10.33588/rn.7009.2020179

Brooks M. COVID-19 Tied to Wide Range of Neuropsychiatric Complications. Medscape. June 29, 2020. https://www.medscape.com/viewarticle/933136

Cormier Z. How Covid-19 can damage the brain. BBC News. 23 June 2020. https://www.bbc.com/future/article/20200622-the-long-term-effects-of-covid-19-infection

Yasgur B.S. Three Stages to COVID-19 Brain Damage, New Review Suggests. Medscape. June 29, 2020. https://www.medscape.com/viewarticle/933131

Negro F. Is antibody-dependent enhancement playing a role in COVID-19 pathogenesis? Swiss Med. Weekly. 2020. 150: w20249. DOI: https://doi.org/10.4414/smw.2020.20249

Coronavirus disease (COVID-19) technical guidance: Laboratory testing for 2019-nCoV in humans. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance/laboratory-guidance

Summary table of available protocols in this document. https://www.who.int/docs/default-source/coronaviruse/whoinhouseassays.pdf?sfvrsn=de3a76aa_2

SARS-CoV-2 Diagnostic Pipeline. https://www.finddx.org/covid-19/pipeline/

Coronavirus Testing Picks Up in the U.S. Following Slow Start. https://www.diagnosticsworldnews.com/news/2020/03/17/coronavirus-testing-picks-up-in-the-u.s.-following-slow-start

Liuqian L., Shulun H., Wei H. 14% of Recovered Covid-19 Patients in Guangdong Tested Positive Again. https://www.caixinglobal.com/2020-02-26/14-of-recovered-covid-19-patients-in-guangdong-tested-positive-again-101520415.html

Omer S.B., Malani P., Del Rio C. The COVID-19 Pandemic in the US: A Clinical Update. JAMA. 2020. DOI: https://doi.org/10.1001/jama.2020.5788

Parry R.L. Coronavirus patients can't relapse, South Korean scientists believe. https://www.thetimes.co.uk/article/coronavirus-patients-cant-relapse-south-korean-scientists-believe-rkm8zm7d9

Ukraine has developed test systems to detect antibodies to coronavirus. The Day. April, 13, 2020. (in Ukrainian). https://day.kyiv.ua/uk/news/130420-ukrayina-rozrobyla-test-systemy-dlya-vyznachennya-antytil-do-koronavirusu

Sona Nanotech Inc. Buy. http://cdn.ceo.ca.s3-us-west-2.amazonaws.com/1f8c1h6-SONA.SNANF.Initiation.Maxim.040220.pdf

Sheridan C. Fast, portable tests come online to curb coronavirus pandemic. https://www.nature.com/articles/d41587-020-00010-2

Fletcher E.R., Vijay S.L. New COVID-19 Rapid Diagnostic Approved On ‘GeneXpert’ TB Platform; Could Pave Way For More Testing In Low- & Middle-Income Countries. https://healthpolicy-watch.org/new-covid-19-rapid-test-approved-for-genexpert-tb-platform-could-pave-way-for-more-testing-in-low-middle-income-countries/

Coronavirus (COVID-19) Update: FDA Authorizes First Antigen Test to Help in the Rapid Detection of the Virus that Causes COVID-19 in Patients. https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-first-antigen-test-help-rapid-detection-virus-causes

Sofia 2 SARS antigen FIA. https://www.quidel.com/immunoassays/rapid-sars-tests/sofia-2-sars-antigen-fia

Medical Companies Win Approval for Rapid Coronavirus Tests. https://www.wsj.com/articles/medical-companies-win-approval-for-rapid-coronavirus-tests-11585586147

Broughton J.P., Deng X., Yu G. et al. CRISPR-Cas12-based detection of SARS-CoV-2. Nat. Biotechnol. 2020. DOI: https://doi.org/10.1038/s41587-020-0513-4

Sanders J.M., Monogue M.L., Jodlowski T.Z., Cutrell J.B. Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19). JAMA. 2020. 323(18): 1824–1836. DOI: https://doi.org/10.1001/jama.2020.6019

Kupferschmidt K., Cohen J. Race to find COVID-19 treatments accelerates. Science. 2020. 367(6485): 1412–1413. DOI: https://doi.org/10.1126/science.367.6485.1412

Rodell C.B. An ACE therapy for COVID-19. https://stm.sciencemag.org/content/12/541/eabb5676

Leslie M. Biologists invent a new way to fight viruses with llama blood and molecular superglue. https://www.sciencemag.org/news/2020/05/biologists-invent-new-way-fight-viruses-llama-blood-and-molecular-super-glue

Mulligan M.J., Lyke K.E., Kitchin N. et al. Phase 1/2 Study to Describe the Safety and Immunogenicity of a COVID-19 RNA Vaccine Candidate (BNT162b1) in Adults 18 to 55 Years of Age: Interim Report. MedRXiv. DOI: https://doi.org/10.1101/2020.06.30.20142570

Ravichandran S., Coyle E.M., Klenow L. et al. Antibody signature induced by SARS-CoV-2 spike protein immunogens in rabbits. Sci. Transl. Med. 2020. 12(550): eabc3539. DOI: https://doi.org/10.1126/scitranslmed.abc3539

Wang C., Li W., Drabek D., Okba N.M.A., van Haperen R., Osterhaus A.D.M.E., van Kuppeveld F.J.M., Haagmans B.L., Grosveld F., Bosch B.J. A human monoclonal antibody blocking SARS-CoV-2 infection. Nat. Commun. 2020. 11(1): 2251. DOI: https://doi.org/10.1038/s41467-020-16256-y

Chi X., Yan R., Zhang J. et al. A Neutralizing Human Antibody Binds to the N-terminal Domain of the Spike Protein of SARS-CoV-2. Science. 369(6504): 650–655. DOI: https://doi.org/10.1126/science.abc6952

Kramer J. Coronavirus Antibody Therapies Raise Hopes — and Skepticism. Scientific American. May 29, 2020. https://www.scientificamerican.com/article/coronavirus-antibody-therapies-raise-hopes-and-skepticism1/

Yuan M., Wu N.C., Zhu X., et al. A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV. Science. 2020. 368(6491): 630–633. DOI: https://doi.org/10.1126/science.abb7269

Jee Ch. A trial is under way of the first new antibody medicine developed to treat COVID-19. https://www.technologyreview.com/2020/06/01/1002475/trial-new-antibody-medicine-developed-to-treat-covid-19/

Robbiani D.F., Gaebler C., Muecksch F. et al. Convergent antibody responses to SARS-CoV-2 in convalescent individuals. Nature. 2020. DOI: https://doi.org/10.1038/s41586-020-2456-9

Kupferschmidt K. Scientists put survivors’ blood plasma to the test. https://science.sciencemag.org/content/368/6494/922

Etherington D. FDA now allows treatment of life-threatening COVID-19 cases using blood from patients who have recovered. https://techcrunch.com/2020/03/24/fda-now-allows-treatment-of-life-threatening-covid-19-cases-using-blood-from-patients-who-have-recovered/

Demura M., Takada N. Blood plasma treatment for coronavirus set for Japan trial. https://asia.nikkei.com/Business/Health-Care/Blood-plasma-treatment-for-coronavirus-set-for-Japan-trial

Gharbharan A., Jordans C.C.E., van Kessel C.G. et al. Convalescent Plasma for COVID-19. A randomized clinical trial. MedRXiv. 2020. DOI: https://doi.org/10.1101/2020.07.01.20139857

Biopharma encourages citizens who have undergone COVID-19 to become plasma donors for the development of drugs against coronavirus infection. Interfax-Ukraine. May, 8, 2020 (in Ukrainian). https://ua.interfax.com.ua/news/general/661051.html

Lovett S. Coronavirus: Men produce more COVID-19 antibodies than women, study shows. https://www.independent.co.uk/news/health/coronavirus-antibodies-men-women-blood-plasma-donor-a9579441.html

The fight against COVID-19 starts with you. https://www.covig-19plasmaalliance.org/en-US#recruitment

Al Idrus A. Takeda, CSL-led alliance and NIH to test COVID-19 plasma treatment this summer. https://www.fiercebiotech.com/biotech/takeda-csl-led-alliance-and-nih-to-test-plasma-treatment-summer

Cohen E. Human Trials Expected To Start Next Month For Covid-19 Treatment Derived From Cows’ Blood. https://www.sabbiotherapeutics.com/2020/06/16/human-trials-expected-to-start-next-month-for-covid-19-treatment-derived-from-cows-blood/

Sheridan C. Convalescent serum lines up as first-choice treatment for coronavirus. https://www.nature.com/articles/d41587-020-00011-1

The first patient tests new drug against COVID-19. https://www.en.auh.dk/press-room/news-archive/2020/the-first-patient-tests-new-drug-against-covid-19/

Camostat Mesylate in COVID-19 Outpatients. https://clinicaltrials.gov/ct2/show/NCT04353284

Devaux C.A., Rolain J.M., Colson P., Raoult D. New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19? Int. J. Antimicrob Agents. 2020. DOI: https://doi.org/10.1016/j.ijantimicag.2020.105938

Piller C. Former FDA leaders decry emergency authorization of malaria drugs for coronavirus. https://www.sciencemag.org/news/2020/04/former-fda-leaders-decry-emergency-authorization-malaria-drugs-coronavirus

Sciama Y. Is France’s president fueling the hype over an unproven coronavirus treatment? https://www.sciencemag.org/news/2020/04/france-s-president-fueling-hype-over-unproven-coronavirus-treatment

Some Swedish hospitals have stopped using chloroquine to treat COVID-19 after reports of severe side effects. https://www.newsweek.com/swedish-hospitals-chloroquine-covid-19-side-effects-1496368

FDA cautions against use of hydroxychloroquine or chloroquine for COVID-19 outside of the hospital setting or a clinical trial due to risk of heart rhythm problems. https://www.fda.gov/drugs/drug-safety-and-availability/fda-cautions-against-use-hydroxychloroquine-or-chloroquine-covid-19-outside-hospital-setting-or

Remdesivir. https://en.wikipedia.org/wiki/Remdesivir#cite_note-:0-4

Yin W., Mao C., Luan X. et al. Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir. Science. 2020. DOI: https://doi.org/10.1126/science.abc1560

Gordon C.J., Tchesnokov E.P., Woolner E., Perry J.K., Feng J.Y., Porter D.P., Gotte M. Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency. J. Biol. Chem. 2020. DOI: https://doi.org/10.1074/jbc.RA120.013679

NIH Clinical Trial Shows Remdesivir Accelerates Recovery from Advanced COVID-19. https://www.niaid.nih.gov/news-events/nih-clinical-trial-shows-remdesivir-accelerates-recovery-advanced-covid-19

Grein J., Ohmagari N., Shin D. et al. Compassionate Use of Remdesivir for Patients with Severe Covid-19. N. Engl. J. Med. 2020. DOI: https://doi.org/10.1056/NEJMoa2007016

FDA Allows For 'Emergency Use' of Remdesivir, Experimental Coronavirus Drug. https://time.com/5831062/fda-allows-emergency-use-remdesivir/

Coronavirus (COVID-19) Update: FDA Issues Emergency Use Authorization for Potential COVID-19 Treatment. https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-issues-emergency-use-authorization-potential-covid-19-treatment

Shimbun A. Japan approves remdesivir for COVID-19 despite uncertainties. http://www.asahi.com/ajw/articles/13358075

Taylor Ph. Remdesivir closes in on receiving first EU approval for treatment for COVID-19. https://www.pmlive.com/pharma_news/remdesivir_closes_in_on_receiving_first_eu_approval_for_treatment_for_covid-19_1343030

Ridgeback Biotherapeutics Announces Launch of Phase 2 Trials Testing EIDD-2801 as Potential Treatment for COVID-19. https://www.businesswire.com/news/home/20200619005038/en/Ridgeback-Biotherapeutics-Announces-Launch-Phase-2-Trials

Lopinavir/ritonavir. https://en.wikipedia.org/wiki/Lopinavir/ritonavir

Choy K.T., Wong A.Y., Kaewpreedee P. et al. Remdesivir, Lopinavir, Emetine, and Homoharringtonine Inhibit SARS-CoV-2 Replication in Vitro. Antiviral Res. 2020. 178: 104786. DOI: https://doi.org/10.1016/j.antiviral.2020.104786

The WHO Solidarity Trial for COVID-19 treatments officially launched in Indonesia. https://www.who.int/indonesia/news/detail/24-04-2020-the-who-solidarity-trial-for-covid-19-treatments-officially-launched-in-indonesia

Li Y., Xie Z., Lin W. et al. An exploratory randomized controlled study on the efficacy and safety of lopinavir/ritonavir or arbidol treating adult patients hospitalized with mild/moderate COVID-19 (ELACOI). DOI: https://doi.org/10.1101/2020.03.19.20038984

Hung I.F., Lung K.C., Tso E.Y. et al. Triple combination of interferon beta-1b, lopinavir-ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial. Lancet. 2020. DOI: https://doi.org/10.1016/S0140-6736(20)31042-4

WHO discontinues hydroxychloroquine and lopinavir/ritonavir treatment arms for COVID-19. https://www.who.int/news-room/detail/04-07-2020-who-discontinues-hydroxychloroquine-and-lopinavir-ritonavir-treatment-arms-for-covid-19

Kadhim A.A.H., Hadi N.R., Abdulhussein M., Zamil S.T., Zamil S.T. Preprocessing of the Candidate Antiviral Drugs against COVID-19 in Models of SARS cov2 Targets. LPMA. 2020. 106(2): 240.

Rossignol J.F., Maisonneuve H. Nitazoxanide in the treatment of Taenia saginata and Hymenolepis nana infections. Am. J.Trop. Med. Hyg. 1984. 33: 511–512. DOI: https://doi.org/10.4269/ajtmh.1984.33.511

Wang M., Cao R., Zhang L., Yang X., Liu J., Xu M., Shi Z., Hu Z., Zhong W., Xiao G. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020. 30(3): 269–271. DOI: https://doi.org/10.1038/s41422-020-0282-0

Scientists Identify 69 Drugs to Test Against the Coronavirus. https://www.nytimes.com/2020/03/22/science/coronavirus-drugs-chloroquine.html

Jin Z., Du X., Xu Y. et al. Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors. Nature. 2020. DOI: https://doi.org/10.1038/s41586-020-2223-y

The Coronavirus Patients Betrayed by Their Own Immune Systems. https://www.nytimes.com/2020/04/01/health/coronavirus-cytokine-storm-immune-system.html

Efficacy and Safety of Emapalumab and Anakinra in Reducing Hyperinflammation and Respiratory Distress in Patients With COVID-19 Infection. https://clinicaltrials.gov/ct2/show/NCT04324021

Sagonowsky E. Roche's Actemra falls short in Italian study in early-stage COVID-19 pneumonia. https://www.fiercepharma.com/pharma/roche-s-actemra-fails-italian-study-early-stage-covid-19-pneumonia

Horby P., Lim W.Sh., Emberson J. et al. RECOVERY Collaborative Group Effect of Dexamethasone in Hospitalized Patients with COVID-19: Preliminary Report. MedRXiv. DOI: https://doi.org/10.1101/2020.06.22.20137273

Poperechna D. MOZ vneslo novyy preparat u protokol likuvannya COVID-19. Ukrayinska pravda. June 25, 2020. https://life.pravda.com.ua/health/2020/06/25/241465/

Yasgur B.S. Colchicine Promising in COVID-19 Treatment? https://www.medscape.com/viewarticle/933198

Day M. Covid-19: ibuprofen should not be used for managing symptoms, say doctors and scientists. https://www.bmj.com/content/368/bmj.m1086

Ioannou P. Rapid Response: Re: Non-steroidal anti-inflammatory drugs and COVID-19; An ambiguous correlation. https://www.bmj.com/content/368/bmj.m1185/rr-0

Godoy M. Concerned About Taking Ibuprofen For Coronavirus Symptoms? Here's What Experts Say. https://www.npr.org/sections/health-shots/2020/03/18/818026613/advice-from-france-to-avoid-ibuprofen-for-covid-19-leaves-experts-baffled

Klok F.A., Kruip M.J.H.A., van der Meer N.J.M., Arbous M.S., Gommers D.A.M.P.J., Kant K.M., Kaptein F.H.J., van Paassen J., Stals M.A.M., Huisman M.V., Endeman H. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thrombosis Research. 2020. DOI: https://doi.org/10.1016/j.thromres.2020.04.013

Tang N., Bai H., Chen X., Gong J., Li D., Sun Z. Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy. Journal of Thrombosis and Haemostasis. 2020. 18(5): 1094–1099. DOI: https://doi.org/10.1111/jth.14817

Lugovskoy E.V., Kolesnikova I.N., Gritsenko P.G., Komissarenko S.V. Utilization of monoclonal antibodies for the quantification of molecular markers of hemostasis. Journal of Thrombosis and Haemostasis. 2003. 1(Suppl. 1): CD084. (XIX Congress of the International Society on Thrombosis and Haemostasis, Birmingham, UK, July 12-18, 2003.)

Lugovskoy E.V., Gritsenko P.G., Kolesnikova I.N., Zolotareva E.N., Chernishov V.I., Nieuwenhuizen W., Komisarenko S.V. Two monoclonal antibodies to D-dimer-specific inhibitors of fibrin polymerization.Thrombosis Research. 2004. 113(3-4): 251–259. DOI: https://doi.org/10.1016/j.thromres.2004.03.005

Collaboration initiated to develop COVID-19 immunotherapy. https://www.drugtargetreview.com/news/58326/collaboration-initiated-to-develop-covid-19-immunotherapy/

Could T-cell immunotherapy be the answer to COVID-19? https://www.drugtargetreview.com/news/60482/could-t-cell-immunotherapy-be-the-answer-to-covid-19/

Borrell B. New York clinical trial quietly tests heartburn remedy against coronavirus. Science. Apr. 26, 2020. DOI: https://doi.org/10.1126/science.abc4739

Koch S., Pong W. First up for COVID-19: nearly 30 clinical readouts before end of April. https://www.biocentury.com/article/304658/nearly-30-trials-for-covid-19-could-start-to-yield-data-in-the-next-couple-of-months

Lim G.Y. TCM and COVID-19: China conducting trials to test efficacy and safety of traditional herbal interventions. https://www.nutraingredients-asia.com/Article/2020/04/06/TCM-and-COVID-19-China-conducting-trials-to-test-efficacy-and-safety-of-traditional-herbal-interventions

Chapin E. Artemisia Annua Could Be Promising Treatment for COVID-19. https://uknow.uky.edu/research/artemisia-annua-could-be-promising-treatment-covid-19

Wadman M. Can interferons stop COVID-19 before it takes hold? Science. 2020: 369(6500): 125–126. DOI: https://doi.org/10.1126/science.369.6500.125

Kupferschmidt K. These Drugs Don’t Target the Coronavirus – They Target Us. https://www.sciencemag.org/news/2020/04/these-drugs-don-t-target-coronavirus-they-target-us

Lipsitch M. Who Is Immune to the Coronavirus? https://www.nytimes.com/2020/04/13/opinion/coronavirus-immunity.html

COVID-19 Antibodies Can Disappear After 2-3 Months, Study Shows. https://www.medscape.com/viewarticle/932671

To K.K.-W., Cheng V.Ch.-Ch., Cai J.-P. et al. Seroprevalence of SARS-CoV-2 in Hong Kong and in residents evacuated from Hubei province, China: a multicohort study. Lancet Microbe. 2020. DOI: https://doi.org/10.1016/S2666-5247(20)30053-7

Dr. Fauci Explains The Timeline And Risks Of Creating A COVID-19 Vaccine. MSNBC. https://www.youtube.com/watch?v=ZrWAqpPGAxQ

CEPI. https://cepi.net/covid-19/

Berkley S. COVID-19 needs a big science approach. https://science.sciencemag.org/content/367/6485/1407

Zheng M., Song L. Novel antibody epitopes dominate the antigenicity of spike glycoprotein in SARS-CoV-2 compared to SARS-CoV. Cell. Mol. Immunol. 2020. 17(5): 536–538. DOI: https://doi.org/10.1038/s41423-020-0385-z

Achenbach J. The coronavirus isn’t mutating quickly, suggesting a vaccine would offer lasting protection. https://www.washingtonpost.com/health/the-coronavirus-isnt-mutating-quickly-suggesting-a-vaccine-would-offer-lasting-protection/2020/03/24/406522d6-6dfd-11ea-b148-e4ce3fbd85b5_story.html

Moderna Announces Positive Interim Phase 1 Data for its mRNA Vaccine (mRNA-1273) Against Novel Coronavirus. https://investors.modernatx.com/news-releases/news-release-details/moderna-announces-positive-interim-phase-1-data-its-mrna-vaccine

Funk C.D., Laferriere C., Ardakani A. A Snapshot of the Global Race for Vaccines Targeting SARS-CoV-2 and the COVID-19 Pandemic. Front. Pharmacol. 2020. 11:937. DOI: https://doi.org/10.3389/fphar.2020.00937

Cohen J. Vaccine designers take first shots at COVID-19. Science. 2020. 368(6486): 14–16. DOI: https://doi.org/10.1126/science.368.6486.14

Callaway E. The race for coronavirus vaccines: a graphical guide. Nature. 2020. 580: 576-577. DOI: https://doi.org/10.1038/d41586-020-01221-y

Gao Q., Bao L., Mao H. et al. Rapid development of an inactivated vaccine candidate for SARS-CoV-2. Science. 2020. 369(6499): eabc1932. DOI: https://doi.org/10.1126/science.abc1932

Mueller S., Stauft C.B., Kalkeri R. et al. A codon-pair deoptimized live-attenuated vaccine against respiratory syncytial virus is immunogenic and efficacious in non-human primates. Vaccine. 2020. 38(14): 2943–2948. DOI: https://doi.org/10.1016/j.vaccine.2020.02.056

Yu J., Tostanoski L.H., Peter L. et al. DNA vaccine protection against SARS-CoV-2 in rhesus macaques. Science. 2020. 20 May 2020: eabc6284. DOI: https://doi.org/10.1126/science.abc6284

Draft landscape of COVID-19 candidate vaccines. WHO. https://www.who.int/who-documents-detail/draft-landscape-of-covid-19-candidate-vaccines

Oxford COVID-19 vaccine to begin phase II/III human trials. http://www.ox.ac.uk/news/2020-05-22-oxford-covid-19-vaccine-begin-phase-iiiii-human-trials

Lauerman J. Oxford, AstraZeneca Begin Advanced Trials of Covid Vaccine. Bloomberg. 22 May 2020. https://www.bloomberg.com/news/articles/2020-05-22/oxford-astrazeneca-begin-advanced-trials-of-covid-vaccine

Folegatti P.M., Ewer K.J., Aley P.K., et al. Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial. The Lancet. 20 July, 2020. DOI: https://doi.org/10.1016/S0140-6736(20)31604-4

Zhu F.-C., Li Y.-H., Gua X.-H. et al. Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial. Lancet. 2020. 395: 1845–1854. DOI: https://doi.org/10.1016/S0140-6736(20)31208-3

Haseltine W.A. Lessons for COVID-19 from the Early Days of AIDS. Scientific American. July 6, 2020.https://www.scientificamerican.com/article/lessons-for-covid-19-from-the-early-days-of-aids/

Accelerating a safe and effective COVID-19 vaccine. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/accelerating-a-safe-and-effective-covid-19-vaccine

Draft landscape of COVID-19 candidate vaccines. WHO. 21 July, 2020. https://www.who.int/who-documents-detail/draft-landscape-of-covid-19-candidate-vaccines

Ramesh S. Can BCG vaccine protect against Covid-19? Here’s why the excitement needs to be tempered. https://theprint.in/science/can-bcg-vaccine-protect-against-covid-19-heres-why-the-excitement-needs-to-be-tempered/401449/

Sparber S. Texas A&M researchers hope tuberculosis vaccine might prevent coronavirus deaths. https://www.krgv.com/news/texas-aandm-researchers-hope-tuberculosis-vaccine-might-prevent-coronavirus-deaths/

Brook B., Harbeson D.J., Shannon C.P. et al. BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis. Sci. Transl. Med. 2020. 12(542): eaax4517. DOI: https://doi.org/10.1126/scitranslmed.aax4517

Arts R.J.W., Moorlag S.J.C.F.M., Novakovic B., Li Y., Wang S.Y., Oosting M., Kumar V., Xavier R.J., Wijmenga C., Joosten L.A.B., Reusken C.B.E.M., Benn C.S., Aaby P., Koopmans M.P., Stunnenberg H.G., van Crevel R., Netea M.G. BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity. Cell Host Microbe. 2018. 23(1): 89–100.e5. DOI: https://doi.org/10.1016/j.chom.2017.12.010

A $10M Grant Enables BCG Vaccine Trial to Expand Internationally, Enrol 10,000 Healthcare Workers. https://www.combacte.com/press-releases/11244/

Chumakov K., Benn C.S., Aaby P., Kottilil Sh., Gallo R. Can existing live vaccines prevent COVID-19? Science. 2020. 368(6496): 1187–1188. DOI: https://doi.org/0.1126/science.abc4262

Escobar L.E., Molina-Cruz A., Barillas-Mury C.BCG vaccine protection from severe coronavirus disease 2019 (COVID-19). PNAS. 2020. 117(30): 17720–17726. DOI: https://doi.org/10.1073/pnas.2008410117

Hamiel U., Kozer E., Youngster I. SARS-CoV-2 Rates in BCG-Vaccinated and Unvaccinated Young Adults. JAMA. 2020. 323(22): 2340–2341. DOI: https://doi.org/10.1001/jama.2020.8189

Woodley M. Healthcare workers trial TB vaccine for coronavirus protection. newsGP. 27 Mar 2020. https://www1.racgp.org.au/newsgp/clinical/healthcare-workers-to-trial-tuberculosis-vaccine-f

Kramer A.E. Decades-Old Soviet Studies Hint at Coronavirus Strategy. https://www.nytimes.com/2020/06/24/world/europe/vaccine-repurposing-polio-coronavirus.html

Report 9: Impact of non-pharmaceutical interventions (NPIs) to reduce COVID-19 mortality and healthcare demand. https://www.imperial.ac.uk/media/imperial-college/medicine/sph/ide/gida-fellowships/Imperial-College-COVID19-NPI-modelling-16-03-2020.pdf

Yang Y.Q., Sun Q., Wang Y.X., et al. Epidemic situation analysis and trend forecast of New Coronavirus Pneumonia (NCP) in Chongqing (in Chinese). Journal of Chongqing Normal University (Natural Science). 2020. 37(1). DOI: https://doi.org/10.1101/2020.02.17.20024034

Brovchenko I. Development of the mathematical model of Covid-19 epidemic spread in Ukraine. Svitohliad. 2020. 2(82): 2–14. (in Ukrainian). https://www.mao.kiev.ua/biblio/jscans/svitogliad/svit-2020-15-2/svitoglyad-2020-2-2-brovchenko.pdf

National coronavirus response: A road map to reopening. https://www.aei.org/research-products/report/national-coronavirus-response-a-road-map-to-reopening/

European countries are easing quarantine restrictions. http://lowcostavia.com.ua/europe-poslablyuye-karantynni-obmezhennya/

Prime Minister Denys Shmyhal unveils a step-by-step quarantine exit plan. Government of Ukraine. Official website. April 24, 2020. https://www.kmu.gov.ua/en/news/premyer-ministr-denis-shmigal-predstaviv-poetapnij-plan-znyattya-obmezhen

Ukrayina perekhodyt do nastupnoho etapu poslablennya karantynu. Ukrayinska pravda. June 1, 2020. (in Ukrainian). https://www.pravda.com.ua/news/2020/06/1/7253960/

Leshner A. Restart science stronger after COVID-19. Science. 2020. 369(6502): 262. DOI: https://doi.org/10.1126 / science.abd5780

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2020-08-21