Complex Diagnosis of Myeloid Neoplasms in Regional Oncological Centers
DOI:
https://doi.org/10.15407/scin9.06.061Keywords:
myeloid neoplasms, chronic myelogenous leukemia, polycythemia vera, primary myelofibrosis, essential thrombocythemia, cytomorphological diagnosis, reverse transcriptase polymerase chain reaction.Abstract
The complex diagnostic system involving cytomorphological, cytochemical, immunocytochemical and molecular genetic study was evaluated and proved to be effective in examining the patients of oncological centers in Ukraine.
References
Swerdlow S.H., Campo E., Harris N.L. et al. WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon: IARC Press. 2008. 439 p.
Jaffe E.S., Harris N.L., Stein H., Vardiman Y.W. Pathology and genetics of tumours of haematopoietic and lymphoid tissues. Lyon: IARC Press. 2001. 351 p.
Murati A., Brecqueville M., Devillier R. et al. Myeloid malignancies: mutations, models and management. BMC Cancer. 2012. V. 12. P. 304.
https://doi.org/10.1186/1471-2407-12-304
Baxter E.J., Scott L.M., Campbell P.J. et al. Acquired mutation of the tyrosine kinase JAK2 in human myelo proliferative disorders. Lancet. 2005. V. 365, No. 9464. P. 1054-1061.
https://doi.org/10.1016/S0140-6736(05)74230-6
Kralovics R., Passamonti F., Buser A.S. et al. A gain-offunction mutation of JAK2 in myeloproliferative di s orders. N Engl J Med. 2005. V. 352, No. 17. P. 1779-1790.
https://doi.org/10.1056/NEJMoa051113
Zhao R., Xing S., Li Z. et al. Identification of an acquired JAK2 mutation in polycythemia vera. J Biol. Chem. 2005. V. 280, No. 24. P. 22788-22792.
https://doi.org/10.1074/jbc.C500138200
Levine R.L., Wadleigh M., Cools J. et al. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell. 2005. V. 7, No. 4. P. 387–397.
https://doi.org/10.1016/j.ccr.2005.03.023
Dybkov M.V., Gartovs'ka I.R., Telegejev G.D., Maljuta S.S. Rozrobka test-systemy dlja vyjavlennja mutacii' V617F gena jak2 u hvoryh na hronichni mijeloproliferatyvni zahvorjuvannja. Nauka innov. 2009, 5(6):59-63 [in Ukrainian].